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PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner

A variant within the gene locus encoding PTPN22 (protein tyrosine phosphatase, non-receptor type 22) emerged as an important risk factor for auto-inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus and type 1 diabetes, but at the same time protects from Crohn disease...

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Detalles Bibliográficos
Autores principales:	Spalinger, Marianne R., Lang, Silvia, Gottier, Claudia, Dai, Xuezhi, Rawlings, David J., Chan, Andrew C., Rogler, Gerhard, Scharl, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Basic Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612532/ https://www.ncbi.nlm.nih.gov/pubmed/28786745 http://dx.doi.org/10.1080/15548627.2017.1341453

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