Cargando…

MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer

AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC). AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT) and a potential therapeutic target for TNBC. In this work, we used microPET/CT with (6...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wanqin, Zhao, Jun, Wen, Xiaoxia, Lin, Curtis Chun-Jen, Li, Junjie, Huang, Qian, Yu, Yongqiang, Lin, Shiaw-Yih, Li, Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612679/ https://www.ncbi.nlm.nih.gov/pubmed/29097911 http://dx.doi.org/10.1155/2017/1686525

Ejemplares similares

Design, Synthesis, and Validation of Axl-Targeted Monoclonal Antibody Probe for microPET Imaging in Human Lung Cancer Xenograft
por: Liu, Shuanglong, et al.
Publicado: (2014)

MicroSPECT and MicroPET Imaging of Small Animals for Drug Development
por: Jang, Beom-Su
Publicado: (2013)

An Optimized MicroPET Imaging Method for the Distribution and Synergies of Natural Products
por: Cui, Qingxin, et al.
Publicado: (2018)

Using MicroPET Imaging in Quantitative Verification of the Acupuncture Effect in Ischemia Stroke Treatment
por: Liu, Huafeng, et al.
Publicado: (2013)

Body distribution of (11)C-methionine and (18)FDG in rat measured by microPET
por: Štolc, Svorad, et al.
Publicado: (2011)

Downregulation of the evolutionary capacitor Hsp90 is mediated by social cues
por: Peuß, Robert, et al.
Publicado: (2015)

(68)Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor Expression
por: Shao, Yahui, et al.
Publicado: (2014)

Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models
por: Lin, Shu-Fu, et al.
Publicado: (2017)

Biodistribution of andrographolide to assess the interior‐exterior relationship between the lung and intestine using microPET
por: Zhang, Qi, et al.
Publicado: (2020)

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
por: Li, Ting, et al.
Publicado: (2018)

Enzyme-Controlled Intracellular Self-Assembly of (18)F Nanoparticles for Enhanced MicroPET Imaging of Tumor
por: Liu, Yaling, et al.
Publicado: (2015)

Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans
por: Gaiser, Andreas M., et al.
Publicado: (2011)

(64)Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression
por: Wu, Zhanhong, et al.
Publicado: (2014)

dAcquisition setting optimization and quantitative imaging for (124)I studies with the Inveon microPET-CT system
por: Anizan, Nadège, et al.
Publicado: (2012)

MicroPET Outperforms Beta-Microprobes in Determining Neuroreceptor Availability under Pharmacological Restriction for Cold Mass Occupancy
por: Glorie, Dorien, et al.
Publicado: (2017)

MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice
por: Kang, ShinWoo, et al.
Publicado: (2022)

Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway
por: Zhang, Mu, et al.
Publicado: (2018)

The Disassociation of the A20/HSP90 Complex via Downregulation of HSP90 Restores the Effect of A20 Enhancing the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents
por: Shen, Li-jun, et al.
Publicado: (2021)

HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer
por: Yang, Haitang, et al.
Publicado: (2019)

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
por: Chang, Cheng, et al.
Publicado: (2023)

[(18)F]VM4-037 MicroPET Imaging and Biodistribution of Two In Vivo CAIX-Expressing Tumor Models
por: Peeters, Sarah G. J. A., et al.
Publicado: (2015)

Utility of (18) F-FDG and (11)C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation
por: English, Sean J, et al.
Publicado: (2014)

Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503
por: Ramakrishnan, Nisha K., et al.
Publicado: (2015)

Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats: A Pilot Study with (18)F-Fluorodeoxyglucose MicroPET
por: Li, Jin-hui, et al.
Publicado: (2013)

Triptolide, a HSP90 middle domain inhibitor, induces apoptosis in triple manner
por: Zhang, Frederick Zhehao, et al.
Publicado: (2018)

Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex
por: Qin, Shurong, et al.
Publicado: (2022)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

Evaluation of the inflammatory response in a two-hit acute lung injury model using [(18)F]FDG microPET
por: ZHOU, GUANG-JU, et al.
Publicado: (2013)

The Use of Longitudinal (18)F-FET MicroPET Imaging to Evaluate Response to Irinotecan in Orthotopic Human Glioblastoma Multiforme Xenografts
por: Nedergaard, Mette K., et al.
Publicado: (2014)

Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT
por: Huber, Jennifer S., et al.
Publicado: (2017)

Quantification of regional murine ozone-induced lung inflammation using [(18)F]F-FDG microPET/CT imaging
por: Aulakh, G. K., et al.
Publicado: (2020)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

Hsp70 and Hsp90 Elaborately Regulate RNAi Efficiency in Plutella xylostella
por: Lin, Sujie, et al.
Publicado: (2023)

SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90
por: Lian, Bin, et al.
Publicado: (2021)

Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before (18)F-FDG Injection: A Preliminary Study with MicroPET
por: Wu, Chenxi, et al.
Publicado: (2011)

MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma
por: Wang, Xintong, et al.
Publicado: (2019)

Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer
por: Ono, Kisho, et al.
Publicado: (2020)

S-glutathionylation of Hsp90 enhances its degradation and correlates with favorable prognosis of breast cancer
por: Shih, Yu-Yin, et al.
Publicado: (2022)

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
por: Usmani, Saad Z, et al.
Publicado: (2010)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_vpojjvoaq2nd5oatug6v52bcut