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Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava

Diabetes is a multifaceted disease with various etiologies. The complexity of this pathology creates a myriad of factors that must be considered when addressing surgical outcomes and prognosis. Of vital importance to cardiovascular surgery is the viability of homographic vein grafts. Due to the fact...

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Autores principales: Rice, Kevin M., Manne, Nandini D.P.K., Arvapalli, Ravikumar, Ginjupalli, Gautam K., Blough, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612793/
https://www.ncbi.nlm.nih.gov/pubmed/28971124
http://dx.doi.org/10.1016/j.dib.2017.09.001
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author Rice, Kevin M.
Manne, Nandini D.P.K.
Arvapalli, Ravikumar
Ginjupalli, Gautam K.
Blough, Eric R.
author_facet Rice, Kevin M.
Manne, Nandini D.P.K.
Arvapalli, Ravikumar
Ginjupalli, Gautam K.
Blough, Eric R.
author_sort Rice, Kevin M.
collection PubMed
description Diabetes is a multifaceted disease with various etiologies. The complexity of this pathology creates a myriad of factors that must be considered when addressing surgical outcomes and prognosis. Of vital importance to cardiovascular surgery is the viability of homographic vein grafts. Due to the fact, diabetic patients have a higher rate of vein graph failure, a greater understanding of the effect diabetes has on vascular mechano-transductive response is critical to improving patient prognosis. This article represents data regarding a study published in Cardiovascular Diabetology (Rice et al., 2006) [1] and Open Journal of Endocrine and Metabolic Diseases (Rice et al., 2015) [2] with the purpose of evaluating the effect of pressurization on rat inferior venae cavae (IVC). Here we provide the information about the method and processing of raw data related to our prior publish work and Data in Brief articles (Rice et al., Submitted for publication) [3,4]. The data contained in this article evaluates the contribution of mTor signaling and associated proteins. IVC from lean and obese animals were exposed to a 30 min perfusion of 120 mm Hg pressure and evaluated for changes in expression and phosphorylation of mTor, p70s6k, GSK3β, and 4EBP-1.
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spelling pubmed-56127932017-10-02 Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava Rice, Kevin M. Manne, Nandini D.P.K. Arvapalli, Ravikumar Ginjupalli, Gautam K. Blough, Eric R. Data Brief Data Article Diabetes is a multifaceted disease with various etiologies. The complexity of this pathology creates a myriad of factors that must be considered when addressing surgical outcomes and prognosis. Of vital importance to cardiovascular surgery is the viability of homographic vein grafts. Due to the fact, diabetic patients have a higher rate of vein graph failure, a greater understanding of the effect diabetes has on vascular mechano-transductive response is critical to improving patient prognosis. This article represents data regarding a study published in Cardiovascular Diabetology (Rice et al., 2006) [1] and Open Journal of Endocrine and Metabolic Diseases (Rice et al., 2015) [2] with the purpose of evaluating the effect of pressurization on rat inferior venae cavae (IVC). Here we provide the information about the method and processing of raw data related to our prior publish work and Data in Brief articles (Rice et al., Submitted for publication) [3,4]. The data contained in this article evaluates the contribution of mTor signaling and associated proteins. IVC from lean and obese animals were exposed to a 30 min perfusion of 120 mm Hg pressure and evaluated for changes in expression and phosphorylation of mTor, p70s6k, GSK3β, and 4EBP-1. Elsevier 2017-09-06 /pmc/articles/PMC5612793/ /pubmed/28971124 http://dx.doi.org/10.1016/j.dib.2017.09.001 Text en © 2017 Tha Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Rice, Kevin M.
Manne, Nandini D.P.K.
Arvapalli, Ravikumar
Ginjupalli, Gautam K.
Blough, Eric R.
Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title_full Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title_fullStr Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title_full_unstemmed Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title_short Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava
title_sort diabetes alters vascular mechanotransduction data: pressure-induced regulation of mtor and associated signaling in the rat inferior vena cava
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612793/
https://www.ncbi.nlm.nih.gov/pubmed/28971124
http://dx.doi.org/10.1016/j.dib.2017.09.001
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