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Predicting metabolic adaptation from networks of mutational paths
Competition for substrates is a ubiquitous selection pressure faced by microbes, yet intracellular trade-offs can prevent cells from metabolizing every type of available substrate. Adaptive evolution is constrained by these trade-offs, but their consequences for the repeatability and predictability...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612958/ https://www.ncbi.nlm.nih.gov/pubmed/28947804 http://dx.doi.org/10.1038/s41467-017-00828-6 |