A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Cells from Bloom’s syndrome patients display genome instability due to a defective BLM and the downregulation of cytidine deaminase. Here, we use a genome-wide RNAi-synthetic lethal screen and transcriptomic profiling to identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells...

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Detalles Bibliográficos
Autores principales: Bou Samra, Elias, Buhagiar-Labarchède, Géraldine, Machon, Christelle, Guitton, Jérôme, Onclercq-Delic, Rosine, Green, Michael R., Alibert, Olivier, Gazin, Claude, Veaute, Xavier, Amor-Guéret, Mounira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612969/
https://www.ncbi.nlm.nih.gov/pubmed/28947735
http://dx.doi.org/10.1038/s41467-017-00633-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612969/
https://www.ncbi.nlm.nih.gov/pubmed/28947735
http://dx.doi.org/10.1038/s41467-017-00633-1

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