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Determinants of the assembly and function of antibody variable domains

The antibody Fv module which binds antigen consists of the variable domains V(L) and V(H). These exhibit a conserved ß-sheet structure and comprise highly variable loops (CDRs). Little is known about the contributions of the framework residues and CDRs to their association. We exchanged conserved in...

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Detalles Bibliográficos
Autores principales:	Herold, Eva Maria, John, Christine, Weber, Benedikt, Kremser, Stephan, Eras, Jonathan, Berner, Carolin, Deubler, Sabrina, Zacharias, Martin, Buchner, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613017/ https://www.ncbi.nlm.nih.gov/pubmed/28947772 http://dx.doi.org/10.1038/s41598-017-12519-9

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