Cargando…

Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis

The present study aimed to evaluate the clinical efficacy and safety of combination therapy comprising desmopressin plus anticholinergic agent compared with desmopressin alone for children with nocturnal enuresis (NE). A meta-analysis of 8 eligible studies was performed to analyze the effects of des...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Jianyong, Yan, Zhaojun, Zhou, Shiying, Han, Feng, Xiao, Feng, Han, Jian, Sun, Congling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613195/
https://www.ncbi.nlm.nih.gov/pubmed/28966673
http://dx.doi.org/10.3892/etm.2017.4897
_version_ 1783266204764340224
author Yu, Jianyong
Yan, Zhaojun
Zhou, Shiying
Han, Feng
Xiao, Feng
Han, Jian
Sun, Congling
author_facet Yu, Jianyong
Yan, Zhaojun
Zhou, Shiying
Han, Feng
Xiao, Feng
Han, Jian
Sun, Congling
author_sort Yu, Jianyong
collection PubMed
description The present study aimed to evaluate the clinical efficacy and safety of combination therapy comprising desmopressin plus anticholinergic agent compared with desmopressin alone for children with nocturnal enuresis (NE). A meta-analysis of 8 eligible studies was performed to analyze the effects of desmopressin plus anticholinergic agent combination therapy and desmopressin monotherapy in the treatment of NE in children. The overall odds ratio (OR) or standardized mean difference (SMD) and 95% confidence interval were calculated for full responders (FR), partial responders (PR), non-responders (NR), the change in the mean number of wet nights and adverse events. Following 1 month of treatment, efficacy analysis yielded an OR of 3.736, which suggested that the proportion of FR for patients treated with the combination therapy was higher than that for patients treated with monotherapy. Analysis of the change in the mean number of wet nights yielded an SMD of 0.719, which indicated that the change in the mean number of wet nights in the patients treated with combination therapy was greater than that in the patients treated with monotherapy. Following 3 months of treatment, the OR calculated for FR plus PR compared with NR was 2.857, indicating that the proportion of FR and PR was elevated by the combination therapy compared with desmopressin alone. The OR for adverse events was 4.074, which suggested that the combination therapy did not lead to more adverse events in the treatment of NE. Therefore, the present meta-analysis suggests that, compared with desmopressin monotherapy, a combination therapy comprising desmopressin and anticholinergic agent is more effective with equivalent safety for children with NE.
format Online
Article
Text
id pubmed-5613195
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-56131952017-09-29 Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis Yu, Jianyong Yan, Zhaojun Zhou, Shiying Han, Feng Xiao, Feng Han, Jian Sun, Congling Exp Ther Med Articles The present study aimed to evaluate the clinical efficacy and safety of combination therapy comprising desmopressin plus anticholinergic agent compared with desmopressin alone for children with nocturnal enuresis (NE). A meta-analysis of 8 eligible studies was performed to analyze the effects of desmopressin plus anticholinergic agent combination therapy and desmopressin monotherapy in the treatment of NE in children. The overall odds ratio (OR) or standardized mean difference (SMD) and 95% confidence interval were calculated for full responders (FR), partial responders (PR), non-responders (NR), the change in the mean number of wet nights and adverse events. Following 1 month of treatment, efficacy analysis yielded an OR of 3.736, which suggested that the proportion of FR for patients treated with the combination therapy was higher than that for patients treated with monotherapy. Analysis of the change in the mean number of wet nights yielded an SMD of 0.719, which indicated that the change in the mean number of wet nights in the patients treated with combination therapy was greater than that in the patients treated with monotherapy. Following 3 months of treatment, the OR calculated for FR plus PR compared with NR was 2.857, indicating that the proportion of FR and PR was elevated by the combination therapy compared with desmopressin alone. The OR for adverse events was 4.074, which suggested that the combination therapy did not lead to more adverse events in the treatment of NE. Therefore, the present meta-analysis suggests that, compared with desmopressin monotherapy, a combination therapy comprising desmopressin and anticholinergic agent is more effective with equivalent safety for children with NE. D.A. Spandidos 2017-10 2017-08-07 /pmc/articles/PMC5613195/ /pubmed/28966673 http://dx.doi.org/10.3892/etm.2017.4897 Text en Copyright: © Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Yu, Jianyong
Yan, Zhaojun
Zhou, Shiying
Han, Feng
Xiao, Feng
Han, Jian
Sun, Congling
Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title_full Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title_fullStr Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title_full_unstemmed Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title_short Desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: A meta-analysis
title_sort desmopressin plus anticholinergic agent in the treatment of nocturnal enuresis: a meta-analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613195/
https://www.ncbi.nlm.nih.gov/pubmed/28966673
http://dx.doi.org/10.3892/etm.2017.4897
work_keys_str_mv AT yujianyong desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT yanzhaojun desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT zhoushiying desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT hanfeng desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT xiaofeng desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT hanjian desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis
AT suncongling desmopressinplusanticholinergicagentinthetreatmentofnocturnalenuresisametaanalysis