Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

CRISPR/Cas9 technology enables efficient loss-of-function analysis of human genes using somatic cells. Studies of essential genes, however, require conditional knockout (KO) cells. Here, we describe the generation of inducible CRISPR KO human cell lines for the subunits of the telosome/shelterin com...

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Detalles Bibliográficos
Autores principales: Kim, Hyeung, Li, Feng, He, Quanyuan, Deng, Tingting, Xu, Jun, Jin, Feng, Coarfa, Cristian, Putluri, Nagireddy, Liu, Dan, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613224/
https://www.ncbi.nlm.nih.gov/pubmed/28955502
http://dx.doi.org/10.1038/celldisc.2017.34

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