The binding property of a monoclonal antibody against the extracellular domains of aquaporin-4 directs aquaporin-4 toward endocytosis

Neuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characterized by an autoantibody called NMO-IgG that recognizes the extracellular domains (ECDs) of aquaporin-4 (AQP4). In this study, monoclonal antibodies (mAbs) against the ECDs of mouse AQP4 were established by a...

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Detalles Bibliográficos
Autores principales: Huang, Ping, Takai, Yoshiki, Kusano-Arai, Osamu, Ramadhanti, Julia, Iwanari, Hiroko, Miyauchi, Takayuki, Sakihama, Toshiko, Han, Jing-Yan, Aoki, Masashi, Hamakubo, Takao, Fujihara, Kazuo, Yasui, Masato, Abe, Yoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613303/
https://www.ncbi.nlm.nih.gov/pubmed/28955892
http://dx.doi.org/10.1016/j.bbrep.2016.05.017

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