Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif “RRQRRL” are critical for fusogenic activity

BACKGROUND: Newcastle disease virus (NDV) causes severe diseases in avian species. Its fusion protein cleavage site (Fcs) is a major contributor to virulence and membrane fusion. Previous studies showed that a change from phenylalanine (F) to lysine (L) at position 117 of the virulent strain fusion...

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Detalles Bibliográficos
Autores principales: Wang, Yanhong, Bi, Youkun, Yu, Wanqi, Wei, Ning, Wang, Wenbin, Wei, Qiaolin, Wang, Xinglong, Zhang, Shuxia, Yang, Zengqi, Xiao, Sa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613334/
https://www.ncbi.nlm.nih.gov/pubmed/28946881
http://dx.doi.org/10.1186/s12985-017-0851-0

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