Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier

Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed...

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Detalles Bibliográficos
Autores principales: Maltas, Esra, Gubbuk, Ilkay Hilal, Yildiz, Salih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613350/
https://www.ncbi.nlm.nih.gov/pubmed/28955907
http://dx.doi.org/10.1016/j.bbrep.2016.06.012
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author Maltas, Esra
Gubbuk, Ilkay Hilal
Yildiz, Salih
author_facet Maltas, Esra
Gubbuk, Ilkay Hilal
Yildiz, Salih
author_sort Maltas, Esra
collection PubMed
description Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis.
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spelling pubmed-56133502017-09-27 Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier Maltas, Esra Gubbuk, Ilkay Hilal Yildiz, Salih Biochem Biophys Rep Research Article Albumin is thought as an drug carrier for doxorubicin (DOX). The binding of doxorubicin to albumin was studied on the surface of sporopolleninin (SP) to produce a new drug system based natural materials. Human serum albumin (HSA) was immobilized on SPIONs in 20 mM Tris buffer, 7.4 of pH. Data showed that binding amount of HSA has been found to be as 285.53 µg to the 25 mg of Sporopolleninin which also bounded 319.76 µM of DOX. Binding of protein and drug to Sp were clarified by SEM, EDX and FT-IR analysis. Elsevier 2016-06-16 /pmc/articles/PMC5613350/ /pubmed/28955907 http://dx.doi.org/10.1016/j.bbrep.2016.06.012 Text en © 2016 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Maltas, Esra
Gubbuk, Ilkay Hilal
Yildiz, Salih
Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title_full Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title_fullStr Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title_full_unstemmed Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title_short Development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
title_sort development of doxorubicin loading platform based albumin-sporopollenin as drug carrier
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613350/
https://www.ncbi.nlm.nih.gov/pubmed/28955907
http://dx.doi.org/10.1016/j.bbrep.2016.06.012
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