Contribution of single amino acid and codon substitutions to the production and secretion of a lipase by Bacillus subtilis

BACKGROUND: Bacillus subtilis produces and secretes proteins in amounts of up to 20 g/l under optimal conditions. However, protein production can be challenging if transcription and cotranslational secretion are negatively affected, or the target protein is degraded by extracellular proteases. This...

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Detalles Bibliográficos
Autores principales: Skoczinski, Pia, Volkenborn, Kristina, Fulton, Alexander, Bhadauriya, Anuseema, Nutschel, Christina, Gohlke, Holger, Knapp, Andreas, Jaeger, Karl-Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613506/
https://www.ncbi.nlm.nih.gov/pubmed/28946879
http://dx.doi.org/10.1186/s12934-017-0772-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613506/
https://www.ncbi.nlm.nih.gov/pubmed/28946879
http://dx.doi.org/10.1186/s12934-017-0772-z

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