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Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm...

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Autores principales: Hussain, Tarique, Tan, Bie, Liu, Gang, Murtaza, Ghulam, Rahu, Najma, Saleem, Muhammad, Yin, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613688/
https://www.ncbi.nlm.nih.gov/pubmed/29138679
http://dx.doi.org/10.1155/2017/8254289
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author Hussain, Tarique
Tan, Bie
Liu, Gang
Murtaza, Ghulam
Rahu, Najma
Saleem, Muhammad
Yin, Yulong
author_facet Hussain, Tarique
Tan, Bie
Liu, Gang
Murtaza, Ghulam
Rahu, Najma
Saleem, Muhammad
Yin, Yulong
author_sort Hussain, Tarique
collection PubMed
description Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγ transcription factors. Flavonoids, which exist in copious amounts in nature, possess a wide array of functions; their supplementation during pregnancy activates Nrf2 signaling pathway which encounters pregnancy disorders. It was further presumed that the development of strong antioxidant uterine environment during gestation can alleviate diseases which appear at adult stages. The purpose of this review is to focus on modulatory properties of flavonoids on oxidative stress-mediated pregnancy insult and abnormal outcomes and role of Nrf2 activation in pregnancy disorders. These findings would be helpful for providing new insights in ameliorating oxidative stress-induced pregnancy disorders.
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spelling pubmed-56136882017-11-14 Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders Hussain, Tarique Tan, Bie Liu, Gang Murtaza, Ghulam Rahu, Najma Saleem, Muhammad Yin, Yulong Oxid Med Cell Longev Review Article Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγ transcription factors. Flavonoids, which exist in copious amounts in nature, possess a wide array of functions; their supplementation during pregnancy activates Nrf2 signaling pathway which encounters pregnancy disorders. It was further presumed that the development of strong antioxidant uterine environment during gestation can alleviate diseases which appear at adult stages. The purpose of this review is to focus on modulatory properties of flavonoids on oxidative stress-mediated pregnancy insult and abnormal outcomes and role of Nrf2 activation in pregnancy disorders. These findings would be helpful for providing new insights in ameliorating oxidative stress-induced pregnancy disorders. Hindawi 2017 2017-08-23 /pmc/articles/PMC5613688/ /pubmed/29138679 http://dx.doi.org/10.1155/2017/8254289 Text en Copyright © 2017 Tarique Hussain et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hussain, Tarique
Tan, Bie
Liu, Gang
Murtaza, Ghulam
Rahu, Najma
Saleem, Muhammad
Yin, Yulong
Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title_full Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title_fullStr Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title_full_unstemmed Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title_short Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
title_sort modulatory mechanism of polyphenols and nrf2 signaling pathway in lps challenged pregnancy disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613688/
https://www.ncbi.nlm.nih.gov/pubmed/29138679
http://dx.doi.org/10.1155/2017/8254289
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