Cargando…

Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery

OBJECTIVE: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration. METHODS: Two samples of approximately 1g of subcutaneous tissue were collected from 19 patients who underwent...

Descripción completa

Detalles Bibliográficos
Autores principales: Tchaick, Rodrigo Mezzalira, Sá, Michel Pompeu Barros Oliveira, Figueira, Fernando Ribeiro de Moraes, Paz, Kilma Coelho, Ferraz, Álvaro Antonio Bandeira, de Moraes Neto, Fernando Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613718/
https://www.ncbi.nlm.nih.gov/pubmed/28977194
http://dx.doi.org/10.21470/1678-9741-2016-0031
_version_ 1783266314723262464
author Tchaick, Rodrigo Mezzalira
Sá, Michel Pompeu Barros Oliveira
Figueira, Fernando Ribeiro de Moraes
Paz, Kilma Coelho
Ferraz, Álvaro Antonio Bandeira
de Moraes Neto, Fernando Ribeiro
author_facet Tchaick, Rodrigo Mezzalira
Sá, Michel Pompeu Barros Oliveira
Figueira, Fernando Ribeiro de Moraes
Paz, Kilma Coelho
Ferraz, Álvaro Antonio Bandeira
de Moraes Neto, Fernando Ribeiro
author_sort Tchaick, Rodrigo Mezzalira
collection PubMed
description OBJECTIVE: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration. METHODS: Two samples of approximately 1g of subcutaneous tissue were collected from 19 patients who underwent surgery in December 2015: the first sample was collected right after sternotomy and the second one, before sternal synthesis with steel wires. Antibiotic dosage was administered through high performance liquid chromatography. RESULTS: We observed a positive and statistically significant correlation between time 1 and cefazolin concentration (r=0.489 and P=0.039). For time 2 and cefazolin concentration, there was a negative and statistically significant correlation between both variables (r=-0.793 and P<0.001). A negative correlation was also observed between body mass index and cefazolin concentration at time 2 (r=-0.510 and P=0.031). The regression model showed that every 1-minute increase in time 1 corresponded to an increase of 0.240 µg/dL in cefazolin concentration, whereas every 1-minute increase in time 2 corresponded to a reduction of 0.046 µg/dL in cefazolin concentration. As for body mass index, every 1 kg/m(2) increase corresponded to a reduction of about 0.510 µg/dL in cefazolin concentration. CONCLUSION: There was a positive and significant correlation between the initial time of surgery and cefazolin level in the first dosage. The evaluation of the second dosage showed a negative and significant correlation between cefazolin level and the second time of dosage. The concentration of cefazolin is under the influence of body mass index.
format Online
Article
Text
id pubmed-5613718
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Sociedade Brasileira de Cirurgia Cardiovascular
record_format MEDLINE/PubMed
spelling pubmed-56137182017-09-29 Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery Tchaick, Rodrigo Mezzalira Sá, Michel Pompeu Barros Oliveira Figueira, Fernando Ribeiro de Moraes Paz, Kilma Coelho Ferraz, Álvaro Antonio Bandeira de Moraes Neto, Fernando Ribeiro Braz J Cardiovasc Surg Original Article OBJECTIVE: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration. METHODS: Two samples of approximately 1g of subcutaneous tissue were collected from 19 patients who underwent surgery in December 2015: the first sample was collected right after sternotomy and the second one, before sternal synthesis with steel wires. Antibiotic dosage was administered through high performance liquid chromatography. RESULTS: We observed a positive and statistically significant correlation between time 1 and cefazolin concentration (r=0.489 and P=0.039). For time 2 and cefazolin concentration, there was a negative and statistically significant correlation between both variables (r=-0.793 and P<0.001). A negative correlation was also observed between body mass index and cefazolin concentration at time 2 (r=-0.510 and P=0.031). The regression model showed that every 1-minute increase in time 1 corresponded to an increase of 0.240 µg/dL in cefazolin concentration, whereas every 1-minute increase in time 2 corresponded to a reduction of 0.046 µg/dL in cefazolin concentration. As for body mass index, every 1 kg/m(2) increase corresponded to a reduction of about 0.510 µg/dL in cefazolin concentration. CONCLUSION: There was a positive and significant correlation between the initial time of surgery and cefazolin level in the first dosage. The evaluation of the second dosage showed a negative and significant correlation between cefazolin level and the second time of dosage. The concentration of cefazolin is under the influence of body mass index. Sociedade Brasileira de Cirurgia Cardiovascular 2017 /pmc/articles/PMC5613718/ /pubmed/28977194 http://dx.doi.org/10.21470/1678-9741-2016-0031 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tchaick, Rodrigo Mezzalira
Sá, Michel Pompeu Barros Oliveira
Figueira, Fernando Ribeiro de Moraes
Paz, Kilma Coelho
Ferraz, Álvaro Antonio Bandeira
de Moraes Neto, Fernando Ribeiro
Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title_full Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title_fullStr Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title_full_unstemmed Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title_short Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery
title_sort cefazolin concentration in the mediastinal adipose tissue of patients undergoing cardiac surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613718/
https://www.ncbi.nlm.nih.gov/pubmed/28977194
http://dx.doi.org/10.21470/1678-9741-2016-0031
work_keys_str_mv AT tchaickrodrigomezzalira cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery
AT samichelpompeubarrosoliveira cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery
AT figueirafernandoribeirodemoraes cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery
AT pazkilmacoelho cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery
AT ferrazalvaroantoniobandeira cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery
AT demoraesnetofernandoribeiro cefazolinconcentrationinthemediastinaladiposetissueofpatientsundergoingcardiacsurgery