Cargando…

Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation

OBJECTIVE: Cardiac surgical operations involving extracorporeal circulation may develop severe inflammatory response. This severe inflammatory response syndrome (SIRS) is usually associated with poor outcome with no predictive marker. Red cell distribution width (RDW) is a routine hematological mark...

Descripción completa

Detalles Bibliográficos
Autores principales: Seth, Harsh Sateesh, Mishra, Prashant, Khandekar, Jayant V., Raut, Chaitanya, Mohapatra, Chandan Kumar Ray, Ammannaya, Ganesh Kumar K., Saini, Jaskaran Singh, Shah, Vaibhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613726/
https://www.ncbi.nlm.nih.gov/pubmed/28977201
http://dx.doi.org/10.21470/1678-9741-2017-0023
_version_ 1783266316583436288
author Seth, Harsh Sateesh
Mishra, Prashant
Khandekar, Jayant V.
Raut, Chaitanya
Mohapatra, Chandan Kumar Ray
Ammannaya, Ganesh Kumar K.
Saini, Jaskaran Singh
Shah, Vaibhav
author_facet Seth, Harsh Sateesh
Mishra, Prashant
Khandekar, Jayant V.
Raut, Chaitanya
Mohapatra, Chandan Kumar Ray
Ammannaya, Ganesh Kumar K.
Saini, Jaskaran Singh
Shah, Vaibhav
author_sort Seth, Harsh Sateesh
collection PubMed
description OBJECTIVE: Cardiac surgical operations involving extracorporeal circulation may develop severe inflammatory response. This severe inflammatory response syndrome (SIRS) is usually associated with poor outcome with no predictive marker. Red cell distribution width (RDW) is a routine hematological marker with a role in inflammation. We aim to determine the relationship between RDW and SIRS through our study. METHODS: A total of 1250 patients who underwent cardiac surgery with extracorporeal circulation were retrospectively analyzed out of which 26 fell into the SIRS criteria and 26 consecutive control patients were taken. RDW, preoperative clinical data, operative time and postoperative data were compared between SIRS and control groups. RESULTS: The demographic profile of the patients was similar. RDW was significantly higher in the SIRS versus control group (15.5±2.0 vs. 13.03±1.90), respectively with P value <0.0001. There was significant mortality in the SIRS group, 20 (76.92%) as compared to 2 (7.6%) in control group with a P value of <0.005. Multiple logistic regression analysis revealed that there was significant association with high RDW and development of SIRS after extracorporeal circulation (OR for RDW levels exceeding 13.5%; 95% CI 1.0-1.2; P<0.05). CONCLUSION: Increased RDW was significantly associated with increased risk of SIRS after extracorporeal circulation. Thus, RDW can act as a useful tool to predict SIRS in patients undergoing cardiac surgery with extracorporeal circulation. Hence, more aggressive measures can be taken in patients with high RDW to prevent postoperative morbidity and mortality.
format Online
Article
Text
id pubmed-5613726
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Sociedade Brasileira de Cirurgia Cardiovascular
record_format MEDLINE/PubMed
spelling pubmed-56137262017-09-29 Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation Seth, Harsh Sateesh Mishra, Prashant Khandekar, Jayant V. Raut, Chaitanya Mohapatra, Chandan Kumar Ray Ammannaya, Ganesh Kumar K. Saini, Jaskaran Singh Shah, Vaibhav Braz J Cardiovasc Surg Original Article OBJECTIVE: Cardiac surgical operations involving extracorporeal circulation may develop severe inflammatory response. This severe inflammatory response syndrome (SIRS) is usually associated with poor outcome with no predictive marker. Red cell distribution width (RDW) is a routine hematological marker with a role in inflammation. We aim to determine the relationship between RDW and SIRS through our study. METHODS: A total of 1250 patients who underwent cardiac surgery with extracorporeal circulation were retrospectively analyzed out of which 26 fell into the SIRS criteria and 26 consecutive control patients were taken. RDW, preoperative clinical data, operative time and postoperative data were compared between SIRS and control groups. RESULTS: The demographic profile of the patients was similar. RDW was significantly higher in the SIRS versus control group (15.5±2.0 vs. 13.03±1.90), respectively with P value <0.0001. There was significant mortality in the SIRS group, 20 (76.92%) as compared to 2 (7.6%) in control group with a P value of <0.005. Multiple logistic regression analysis revealed that there was significant association with high RDW and development of SIRS after extracorporeal circulation (OR for RDW levels exceeding 13.5%; 95% CI 1.0-1.2; P<0.05). CONCLUSION: Increased RDW was significantly associated with increased risk of SIRS after extracorporeal circulation. Thus, RDW can act as a useful tool to predict SIRS in patients undergoing cardiac surgery with extracorporeal circulation. Hence, more aggressive measures can be taken in patients with high RDW to prevent postoperative morbidity and mortality. Sociedade Brasileira de Cirurgia Cardiovascular 2017 /pmc/articles/PMC5613726/ /pubmed/28977201 http://dx.doi.org/10.21470/1678-9741-2017-0023 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Seth, Harsh Sateesh
Mishra, Prashant
Khandekar, Jayant V.
Raut, Chaitanya
Mohapatra, Chandan Kumar Ray
Ammannaya, Ganesh Kumar K.
Saini, Jaskaran Singh
Shah, Vaibhav
Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title_full Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title_fullStr Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title_full_unstemmed Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title_short Relationship between High Red Cell Distribution Width and Systemic Inflammatory Response Syndrome after Extracorporeal Circulation
title_sort relationship between high red cell distribution width and systemic inflammatory response syndrome after extracorporeal circulation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613726/
https://www.ncbi.nlm.nih.gov/pubmed/28977201
http://dx.doi.org/10.21470/1678-9741-2017-0023
work_keys_str_mv AT sethharshsateesh relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT mishraprashant relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT khandekarjayantv relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT rautchaitanya relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT mohapatrachandankumarray relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT ammannayaganeshkumark relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT sainijaskaransingh relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation
AT shahvaibhav relationshipbetweenhighredcelldistributionwidthandsystemicinflammatoryresponsesyndromeafterextracorporealcirculation