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Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies

Mutations in the human SLC26A4/Pendrin polypeptide (hPDS) cause Pendred Syndrome /DFNB4, syndromic deafness with enlargement of the vestibular aqueduct and low-penetrance goiter. Here we present data on cloning, protein overexpression and purification, refolding, and biophysical characterization of...

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Detalles Bibliográficos
Autores principales:	Sharma, Alok K., Krieger, Tobias, Rigby, Alan C., Zelikovic, Israel, Alper, Seth L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613929/ https://www.ncbi.nlm.nih.gov/pubmed/28955955 http://dx.doi.org/10.1016/j.bbrep.2016.08.022

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