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Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter

The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with di...

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Autores principales: Wang, Jialin, Huang, Mi, Yang, Jie, Ma, Xinhua, Zheng, Sijian, Deng, Shihao, Huang, Yun, Yang, Xinzhou, Zhao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614214/
https://www.ncbi.nlm.nih.gov/pubmed/28970778
http://dx.doi.org/10.1080/16546628.2017.1364117
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author Wang, Jialin
Huang, Mi
Yang, Jie
Ma, Xinhua
Zheng, Sijian
Deng, Shihao
Huang, Yun
Yang, Xinzhou
Zhao, Ping
author_facet Wang, Jialin
Huang, Mi
Yang, Jie
Ma, Xinhua
Zheng, Sijian
Deng, Shihao
Huang, Yun
Yang, Xinzhou
Zhao, Ping
author_sort Wang, Jialin
collection PubMed
description The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression.
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spelling pubmed-56142142017-10-02 Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter Wang, Jialin Huang, Mi Yang, Jie Ma, Xinhua Zheng, Sijian Deng, Shihao Huang, Yun Yang, Xinzhou Zhao, Ping Food Nutr Res Original Article The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression. Taylor & Francis 2017-08-23 /pmc/articles/PMC5614214/ /pubmed/28970778 http://dx.doi.org/10.1080/16546628.2017.1364117 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wang, Jialin
Huang, Mi
Yang, Jie
Ma, Xinhua
Zheng, Sijian
Deng, Shihao
Huang, Yun
Yang, Xinzhou
Zhao, Ping
Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title_full Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title_fullStr Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title_full_unstemmed Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title_short Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
title_sort anti-diabetic activity of stigmasterol from soybean oil by targeting the glut4 glucose transporter
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614214/
https://www.ncbi.nlm.nih.gov/pubmed/28970778
http://dx.doi.org/10.1080/16546628.2017.1364117
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