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Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter
The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with di...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614214/ https://www.ncbi.nlm.nih.gov/pubmed/28970778 http://dx.doi.org/10.1080/16546628.2017.1364117 |
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author | Wang, Jialin Huang, Mi Yang, Jie Ma, Xinhua Zheng, Sijian Deng, Shihao Huang, Yun Yang, Xinzhou Zhao, Ping |
author_facet | Wang, Jialin Huang, Mi Yang, Jie Ma, Xinhua Zheng, Sijian Deng, Shihao Huang, Yun Yang, Xinzhou Zhao, Ping |
author_sort | Wang, Jialin |
collection | PubMed |
description | The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression. |
format | Online Article Text |
id | pubmed-5614214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-56142142017-10-02 Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter Wang, Jialin Huang, Mi Yang, Jie Ma, Xinhua Zheng, Sijian Deng, Shihao Huang, Yun Yang, Xinzhou Zhao, Ping Food Nutr Res Original Article The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind of phytosterols derived from the edible soybean oil in vitro and in vivo. SMR displayed a mild GLUT4 translocation activity by 1.44-fold in L6 cells. L6 cells were treated with different concentration of SMR, showing significant effects on the enhancing glucose uptake. SMR administrated orally to the KK-Ay mice significantly alleviated their insulin resistance and oral glucose tolerance with reducing fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, the GLUT4 expression in L6 cells, skeletal muscle and white adipose tissue had been also enhanced. In this paper we conclude that, stigmasterol seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of targeting GLUT4 glucose transporter included increasing GLUT4 translocation and expression. Taylor & Francis 2017-08-23 /pmc/articles/PMC5614214/ /pubmed/28970778 http://dx.doi.org/10.1080/16546628.2017.1364117 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Wang, Jialin Huang, Mi Yang, Jie Ma, Xinhua Zheng, Sijian Deng, Shihao Huang, Yun Yang, Xinzhou Zhao, Ping Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title_full | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title_fullStr | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title_full_unstemmed | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title_short | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
title_sort | anti-diabetic activity of stigmasterol from soybean oil by targeting the glut4 glucose transporter |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614214/ https://www.ncbi.nlm.nih.gov/pubmed/28970778 http://dx.doi.org/10.1080/16546628.2017.1364117 |
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