Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (Gln) is one such nutrient that is rapidly taken up by tumor cells to fulfill this increased metabolic demand. A vital...

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Detalles Bibliográficos
Autores principales: Lampa, Michael, Arlt, Heike, He, Timothy, Ospina, Beatriz, Reeves, Jason, Zhang, Bailin, Murtie, Joshua, Deng, Gejing, Barberis, Claude, Hoffmann, Dietmar, Cheng, Hong, Pollard, Jack, Winter, Christopher, Richon, Victoria, Garcia-Escheverria, Carlos, Adrian, Francisco, Wiederschain, Dmitri, Srinivasan, Lakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614427/
https://www.ncbi.nlm.nih.gov/pubmed/28950000
http://dx.doi.org/10.1371/journal.pone.0185092

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