PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

The mitochondrial unfolded protein response (UPR(mt)) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPR(mt) reporters and extends lifespan. We show that similar developmental stress is necessary and sufficient to...

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Detalles Bibliográficos
Autores principales: Borch Jensen, Martin, Qi, Yanyan, Riley, Rebeccah, Rabkina, Liya, Jasper, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614561/
https://www.ncbi.nlm.nih.gov/pubmed/28891792
http://dx.doi.org/10.7554/eLife.26952

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