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Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding domain (CNBD) in their C-terminal region linked to the pore-forming transmembrane segment with a C-linker. The C-linker couples the conforma...

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Detalles Bibliográficos
Autores principales:	Hayoz, Sebastien, Tiwari, Purushottam B., Piszczek, Grzegorz, Üren, Aykut, Brelidze, Tinatin I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614581/ https://www.ncbi.nlm.nih.gov/pubmed/28950029 http://dx.doi.org/10.1371/journal.pone.0185359

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