Specific titin and myomesin domains stimulate myoblast proliferation

Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains w...

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Detalles Bibliográficos
Autores principales: Kravchenko, Irina V., Furalyov, Vladimir A., Popov, Vladimir O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614584/
https://www.ncbi.nlm.nih.gov/pubmed/28956009
http://dx.doi.org/10.1016/j.bbrep.2016.12.007
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author Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
author_facet Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
author_sort Kravchenko, Irina V.
collection PubMed
description Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains was highly sensitive to inhibition of Ca(2+)/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of adenylyl cyclase – cAMP – PKA pathway. IGF-1 autocrine signalling inhibition partially suppressed mitogenic effects revealed by both domain types.
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spelling pubmed-56145842017-09-27 Specific titin and myomesin domains stimulate myoblast proliferation Kravchenko, Irina V. Furalyov, Vladimir A. Popov, Vladimir O. Biochem Biophys Rep Research Article Myofibrillar proteins titin and myomesin stimulated myoblast proliferation as determined by MTT-test and labelled thymidine incorporation in the DNA. Specific Fn type III and Ig-like domains of these proteins were able to exert mitogenic effects as well. Proliferative effect of Fn type III domains was highly sensitive to inhibition of Ca(2+)/calmodulin dependent protein kinase, whereas the effect of Ig-like domains showed greater sensitivity to the inhibition of adenylyl cyclase – cAMP – PKA pathway. IGF-1 autocrine signalling inhibition partially suppressed mitogenic effects revealed by both domain types. Elsevier 2016-12-30 /pmc/articles/PMC5614584/ /pubmed/28956009 http://dx.doi.org/10.1016/j.bbrep.2016.12.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kravchenko, Irina V.
Furalyov, Vladimir A.
Popov, Vladimir O.
Specific titin and myomesin domains stimulate myoblast proliferation
title Specific titin and myomesin domains stimulate myoblast proliferation
title_full Specific titin and myomesin domains stimulate myoblast proliferation
title_fullStr Specific titin and myomesin domains stimulate myoblast proliferation
title_full_unstemmed Specific titin and myomesin domains stimulate myoblast proliferation
title_short Specific titin and myomesin domains stimulate myoblast proliferation
title_sort specific titin and myomesin domains stimulate myoblast proliferation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614584/
https://www.ncbi.nlm.nih.gov/pubmed/28956009
http://dx.doi.org/10.1016/j.bbrep.2016.12.007
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