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CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients

DM domain transcription factors play important roles in sexual development in a wide variety of species from invertebrate to humans. Among seven mammalian family members of DM domain transcription factors, DMRT1 has been studied in mouse and human for its conserved role in male gonadal identity. Chr...

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Detalles Bibliográficos
Autores principales:	Inui, Masafumi, Tamano, Moe, Kato, Tomoko, Takada, Shuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614593/ https://www.ncbi.nlm.nih.gov/pubmed/28956011 http://dx.doi.org/10.1016/j.bbrep.2017.01.001

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