Cargando…
Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology
ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myost...
Autores principales: | Sakamoto, Kotaro, Kanematsu-Yamaki, Yoko, Kamada, Yusuke, Oka, Masahiro, Ohnishi, Toshiyuki, Miwa, Masanori, Asami, Taiji, Inooka, Hiroshi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614685/ https://www.ncbi.nlm.nih.gov/pubmed/28955765 http://dx.doi.org/10.1016/j.bbrep.2017.06.001 |
Ejemplares similares
-
Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
por: Goncalves, Marcus D., et al.
Publicado: (2010) -
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
por: Queiroz, Andre Lima, et al.
Publicado: (2022) -
Preliminary Investigation into a Potential Role for Myostatin and Its Receptor (ActRIIB) in Lean and Obese Horses and Ponies
por: Morrison, Philippa K., et al.
Publicado: (2014) -
Adult-Specific Systemic Over-Expression Reveals Novel In Vivo Effects of the Soluble Forms of ActRIIA, ActRIIB and BMPRII
por: Yamawaki, Kengo, et al.
Publicado: (2013) -
Electrical impedance myography as a biomarker of myostatin inhibition with ActRIIB-mFc: a study in wild-type mice
por: Nagy, Janice A, et al.
Publicado: (2018)