Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy()()

Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resectio...

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Detalles Bibliográficos
Autores principales: Harryman, William L., Gard, Jaime M.C., Pond, Kelvin W., Simpson, Skyler J., Heppner, Lucas H., Hernandez-Cortes, Daniel, Little, Andrew S., Eschbacher, Jennifer M., Cress, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614733/
https://www.ncbi.nlm.nih.gov/pubmed/28954241
http://dx.doi.org/10.1016/j.neo.2017.08.005

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