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Schizophrenia and sleep disorders: links, risks, and management challenges

Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally conside...

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Autores principales: Kaskie, Rachel E, Graziano, Bianca, Ferrarelli, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614792/
https://www.ncbi.nlm.nih.gov/pubmed/29033618
http://dx.doi.org/10.2147/NSS.S121076
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author Kaskie, Rachel E
Graziano, Bianca
Ferrarelli, Fabio
author_facet Kaskie, Rachel E
Graziano, Bianca
Ferrarelli, Fabio
author_sort Kaskie, Rachel E
collection PubMed
description Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally considered the most prominent features of this disorder, the role of sleep and sleep disturbances has gained increasing prominence in clinical practice. Indeed, the vast majority of patients with schizophrenia report sleep abnormalities, which tend to precede illness onset and can predict an acute exacerbation of psychotic symptoms. Furthermore, schizophrenia patients often have a comorbid sleep disorder, including insomnia, obstructive sleep apnea, restless leg syndrome, or periodic limb movement disorder. Despite accumulating data, the links between sleep disorders and schizophrenia have not been thoroughly examined, in part because they are difficult to disentangle, as numerous factors contribute to their comorbidity, including medication status. Additionally, sleep disorders are often not the primary focus of clinicians treating this population, despite studies suggesting that comorbid sleep disorders carry their own unique risks, including worsening of psychotic symptoms and poorer quality of life. There is also limited information about effective management strategies for schizophrenia patients affected by significant sleep disturbances and/or sleep disorders. To begin addressing these issues, the present review will systematically examine the literature on sleep disorders and schizophrenia, focusing on studies related to 1) links between distinct sleep disorders and schizophrenia; 2) risks unique to patients with a comorbid sleep disorder; and 3) and management challenges and strategies.
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spelling pubmed-56147922017-10-13 Schizophrenia and sleep disorders: links, risks, and management challenges Kaskie, Rachel E Graziano, Bianca Ferrarelli, Fabio Nat Sci Sleep Review Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally considered the most prominent features of this disorder, the role of sleep and sleep disturbances has gained increasing prominence in clinical practice. Indeed, the vast majority of patients with schizophrenia report sleep abnormalities, which tend to precede illness onset and can predict an acute exacerbation of psychotic symptoms. Furthermore, schizophrenia patients often have a comorbid sleep disorder, including insomnia, obstructive sleep apnea, restless leg syndrome, or periodic limb movement disorder. Despite accumulating data, the links between sleep disorders and schizophrenia have not been thoroughly examined, in part because they are difficult to disentangle, as numerous factors contribute to their comorbidity, including medication status. Additionally, sleep disorders are often not the primary focus of clinicians treating this population, despite studies suggesting that comorbid sleep disorders carry their own unique risks, including worsening of psychotic symptoms and poorer quality of life. There is also limited information about effective management strategies for schizophrenia patients affected by significant sleep disturbances and/or sleep disorders. To begin addressing these issues, the present review will systematically examine the literature on sleep disorders and schizophrenia, focusing on studies related to 1) links between distinct sleep disorders and schizophrenia; 2) risks unique to patients with a comorbid sleep disorder; and 3) and management challenges and strategies. Dove Medical Press 2017-09-21 /pmc/articles/PMC5614792/ /pubmed/29033618 http://dx.doi.org/10.2147/NSS.S121076 Text en © 2017 Kaskie et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Kaskie, Rachel E
Graziano, Bianca
Ferrarelli, Fabio
Schizophrenia and sleep disorders: links, risks, and management challenges
title Schizophrenia and sleep disorders: links, risks, and management challenges
title_full Schizophrenia and sleep disorders: links, risks, and management challenges
title_fullStr Schizophrenia and sleep disorders: links, risks, and management challenges
title_full_unstemmed Schizophrenia and sleep disorders: links, risks, and management challenges
title_short Schizophrenia and sleep disorders: links, risks, and management challenges
title_sort schizophrenia and sleep disorders: links, risks, and management challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614792/
https://www.ncbi.nlm.nih.gov/pubmed/29033618
http://dx.doi.org/10.2147/NSS.S121076
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