AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

A causative understanding of genetic factors that regulate glioblastoma (GBM) pathogenesis is of central importance. Here, we developed an adeno-associated virus (AAV)-mediated autochthonous CRISPR screen in GBM. Stereotaxic delivery of an AAV library targeting genes commonly mutated in human cancer...

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Detalles Bibliográficos
Autores principales: Chow, Ryan D., Guzman, Christopher D., Wang, Guangchuan, Schmidt, Florian, Youngblood, Mark W., Ye, Lupeng, Errami, Youssef, Dong, Matthew B., Martinez, Michael A., Zhang, Sensen, Renauer, Paul, Bilguvar, Kaya, Gunel, Murat, Sharp, Phillip A., Zhang, Feng, Platt, Randall J., Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614841/
https://www.ncbi.nlm.nih.gov/pubmed/28805815
http://dx.doi.org/10.1038/nn.4620

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