Genetics in an isolated population like Finland: a different basis for genomic medicine?

A unique genetic background in an isolated population like that of Finland offers special opportunities for genetic research as well as for applying the genetic developments to the health care. On the other hand, the different genetic background may require local attempts to develop diagnostics and...

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Autores principales: Kääriäinen, Helena, Muilu, Juha, Perola, Markus, Kristiansson, Kati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614886/
https://www.ncbi.nlm.nih.gov/pubmed/28730583
http://dx.doi.org/10.1007/s12687-017-0318-4
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author Kääriäinen, Helena
Muilu, Juha
Perola, Markus
Kristiansson, Kati
author_facet Kääriäinen, Helena
Muilu, Juha
Perola, Markus
Kristiansson, Kati
author_sort Kääriäinen, Helena
collection PubMed
description A unique genetic background in an isolated population like that of Finland offers special opportunities for genetic research as well as for applying the genetic developments to the health care. On the other hand, the different genetic background may require local attempts to develop diagnostics and treatment as the selection of diseases and mutations differs from that in the other populations. In this review, we describe the experiences of research and health care in this genetic isolate starting from the identification of specific monogenic diseases enriched in the Finnish population all the way to implementing the knowledge of the unique genetic background to genomic medicine at population level.
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spelling pubmed-56148862017-10-11 Genetics in an isolated population like Finland: a different basis for genomic medicine? Kääriäinen, Helena Muilu, Juha Perola, Markus Kristiansson, Kati J Community Genet Original Article A unique genetic background in an isolated population like that of Finland offers special opportunities for genetic research as well as for applying the genetic developments to the health care. On the other hand, the different genetic background may require local attempts to develop diagnostics and treatment as the selection of diseases and mutations differs from that in the other populations. In this review, we describe the experiences of research and health care in this genetic isolate starting from the identification of specific monogenic diseases enriched in the Finnish population all the way to implementing the knowledge of the unique genetic background to genomic medicine at population level. Springer Berlin Heidelberg 2017-07-20 2017-10 /pmc/articles/PMC5614886/ /pubmed/28730583 http://dx.doi.org/10.1007/s12687-017-0318-4 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Kääriäinen, Helena
Muilu, Juha
Perola, Markus
Kristiansson, Kati
Genetics in an isolated population like Finland: a different basis for genomic medicine?
title Genetics in an isolated population like Finland: a different basis for genomic medicine?
title_full Genetics in an isolated population like Finland: a different basis for genomic medicine?
title_fullStr Genetics in an isolated population like Finland: a different basis for genomic medicine?
title_full_unstemmed Genetics in an isolated population like Finland: a different basis for genomic medicine?
title_short Genetics in an isolated population like Finland: a different basis for genomic medicine?
title_sort genetics in an isolated population like finland: a different basis for genomic medicine?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614886/
https://www.ncbi.nlm.nih.gov/pubmed/28730583
http://dx.doi.org/10.1007/s12687-017-0318-4
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