Natural Killer T Cells in Cancer Immunotherapy

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunother...

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Detalles Bibliográficos
Autores principales: Nair, Shiny, Dhodapkar, Madhav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614937/
https://www.ncbi.nlm.nih.gov/pubmed/29018445
http://dx.doi.org/10.3389/fimmu.2017.01178
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author Nair, Shiny
Dhodapkar, Madhav V.
author_facet Nair, Shiny
Dhodapkar, Madhav V.
author_sort Nair, Shiny
collection PubMed
description Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future perspectives to better harness the potential of NKT cells for cancer therapy.
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spelling pubmed-56149372017-10-10 Natural Killer T Cells in Cancer Immunotherapy Nair, Shiny Dhodapkar, Madhav V. Front Immunol Immunology Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future perspectives to better harness the potential of NKT cells for cancer therapy. Frontiers Media S.A. 2017-09-22 /pmc/articles/PMC5614937/ /pubmed/29018445 http://dx.doi.org/10.3389/fimmu.2017.01178 Text en Copyright © 2017 Nair and Dhodapkar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Nair, Shiny
Dhodapkar, Madhav V.
Natural Killer T Cells in Cancer Immunotherapy
title Natural Killer T Cells in Cancer Immunotherapy
title_full Natural Killer T Cells in Cancer Immunotherapy
title_fullStr Natural Killer T Cells in Cancer Immunotherapy
title_full_unstemmed Natural Killer T Cells in Cancer Immunotherapy
title_short Natural Killer T Cells in Cancer Immunotherapy
title_sort natural killer t cells in cancer immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614937/
https://www.ncbi.nlm.nih.gov/pubmed/29018445
http://dx.doi.org/10.3389/fimmu.2017.01178
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AT dhodapkarmadhavv naturalkillertcellsincancerimmunotherapy

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