A 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock(®))

Fernblock(®) is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock(®), no genotoxicy was observed and no oral toxicity was observed up...

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Detalles Bibliográficos
Autores principales: Murbach, Timothy S., Glávits, Róbert, Hirka, Gábor, Endres, John R., Clewell, Amy E., Szakonyiné, Ilona Pasics
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615158/
https://www.ncbi.nlm.nih.gov/pubmed/28959679
http://dx.doi.org/10.1016/j.toxrep.2017.09.002
Descripción
Sumario:Fernblock(®) is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock(®), no genotoxicy was observed and no oral toxicity was observed up to 1200 mg/kg bw/day. The current study was conducted in Hsd.Han Wistar rats using doses of 0, 2000, 3500, and 5000 mg/kg bw/day Fernblock(®) by gavage for 28 consecutive days. No mortality or toxic effects were observed and no target organs were identified. The no observed adverse effect level was determined to be 5000 mg/kg bw/day, the highest dose tested.

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