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A severe myopathy case in aged patient treated with high statin dosage

Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressiv...

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Autores principales: Elena, Canzonieri, Cristina, De Candia, Salvatore, Tarascio, Silvia, Giamporcaro, Giovanni, Lumera, Giuseppe, Rigano, Carmela, Incognito, Filippo, Privitera, Agata, Guarnaccia, Valerio, Foti Pietro, Stefano, Palmucci, Pietro, Gangemi, Giulia, Fuccio-Sanzà, Santo, Signorelli Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615159/
https://www.ncbi.nlm.nih.gov/pubmed/28959671
http://dx.doi.org/10.1016/j.toxrep.2017.07.009
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author Elena, Canzonieri
Cristina, De Candia
Salvatore, Tarascio
Silvia, Giamporcaro
Giovanni, Lumera
Giuseppe, Rigano
Carmela, Incognito
Filippo, Privitera
Agata, Guarnaccia
Valerio, Foti Pietro
Stefano, Palmucci
Pietro, Gangemi
Giulia, Fuccio-Sanzà
Santo, Signorelli Salvatore
author_facet Elena, Canzonieri
Cristina, De Candia
Salvatore, Tarascio
Silvia, Giamporcaro
Giovanni, Lumera
Giuseppe, Rigano
Carmela, Incognito
Filippo, Privitera
Agata, Guarnaccia
Valerio, Foti Pietro
Stefano, Palmucci
Pietro, Gangemi
Giulia, Fuccio-Sanzà
Santo, Signorelli Salvatore
author_sort Elena, Canzonieri
collection PubMed
description Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagnosis of necrotizing autoimmune myopathy (NAM). We believe that the clinical case described here is a useful report of this rare toxicity and we aim to highlight the importance of its prompt recognition and treatment.
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spelling pubmed-56151592017-09-28 A severe myopathy case in aged patient treated with high statin dosage Elena, Canzonieri Cristina, De Candia Salvatore, Tarascio Silvia, Giamporcaro Giovanni, Lumera Giuseppe, Rigano Carmela, Incognito Filippo, Privitera Agata, Guarnaccia Valerio, Foti Pietro Stefano, Palmucci Pietro, Gangemi Giulia, Fuccio-Sanzà Santo, Signorelli Salvatore Toxicol Rep Case Report Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagnosis of necrotizing autoimmune myopathy (NAM). We believe that the clinical case described here is a useful report of this rare toxicity and we aim to highlight the importance of its prompt recognition and treatment. Elsevier 2017-08-01 /pmc/articles/PMC5615159/ /pubmed/28959671 http://dx.doi.org/10.1016/j.toxrep.2017.07.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Elena, Canzonieri
Cristina, De Candia
Salvatore, Tarascio
Silvia, Giamporcaro
Giovanni, Lumera
Giuseppe, Rigano
Carmela, Incognito
Filippo, Privitera
Agata, Guarnaccia
Valerio, Foti Pietro
Stefano, Palmucci
Pietro, Gangemi
Giulia, Fuccio-Sanzà
Santo, Signorelli Salvatore
A severe myopathy case in aged patient treated with high statin dosage
title A severe myopathy case in aged patient treated with high statin dosage
title_full A severe myopathy case in aged patient treated with high statin dosage
title_fullStr A severe myopathy case in aged patient treated with high statin dosage
title_full_unstemmed A severe myopathy case in aged patient treated with high statin dosage
title_short A severe myopathy case in aged patient treated with high statin dosage
title_sort severe myopathy case in aged patient treated with high statin dosage
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615159/
https://www.ncbi.nlm.nih.gov/pubmed/28959671
http://dx.doi.org/10.1016/j.toxrep.2017.07.009
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