Cargando…
A severe myopathy case in aged patient treated with high statin dosage
Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressiv...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615159/ https://www.ncbi.nlm.nih.gov/pubmed/28959671 http://dx.doi.org/10.1016/j.toxrep.2017.07.009 |
_version_ | 1783266531597090816 |
---|---|
author | Elena, Canzonieri Cristina, De Candia Salvatore, Tarascio Silvia, Giamporcaro Giovanni, Lumera Giuseppe, Rigano Carmela, Incognito Filippo, Privitera Agata, Guarnaccia Valerio, Foti Pietro Stefano, Palmucci Pietro, Gangemi Giulia, Fuccio-Sanzà Santo, Signorelli Salvatore |
author_facet | Elena, Canzonieri Cristina, De Candia Salvatore, Tarascio Silvia, Giamporcaro Giovanni, Lumera Giuseppe, Rigano Carmela, Incognito Filippo, Privitera Agata, Guarnaccia Valerio, Foti Pietro Stefano, Palmucci Pietro, Gangemi Giulia, Fuccio-Sanzà Santo, Signorelli Salvatore |
author_sort | Elena, Canzonieri |
collection | PubMed |
description | Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagnosis of necrotizing autoimmune myopathy (NAM). We believe that the clinical case described here is a useful report of this rare toxicity and we aim to highlight the importance of its prompt recognition and treatment. |
format | Online Article Text |
id | pubmed-5615159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56151592017-09-28 A severe myopathy case in aged patient treated with high statin dosage Elena, Canzonieri Cristina, De Candia Salvatore, Tarascio Silvia, Giamporcaro Giovanni, Lumera Giuseppe, Rigano Carmela, Incognito Filippo, Privitera Agata, Guarnaccia Valerio, Foti Pietro Stefano, Palmucci Pietro, Gangemi Giulia, Fuccio-Sanzà Santo, Signorelli Salvatore Toxicol Rep Case Report Statins (S) are widely used drugs for cardiovascular prevention however their utilization may cause a various grade of muscle toxicity. Sometime S discontinuation alone is not sufficient to revert muscle injury and this can evolve in serious inflammatory muscle disease. In this case immunosuppressive medications are required to achieve remission. This case report describes a patient who developed rhabdomyolysis after recent S treatment initiation and the diagnostic work up have lead to the diagnosis of necrotizing autoimmune myopathy (NAM). We believe that the clinical case described here is a useful report of this rare toxicity and we aim to highlight the importance of its prompt recognition and treatment. Elsevier 2017-08-01 /pmc/articles/PMC5615159/ /pubmed/28959671 http://dx.doi.org/10.1016/j.toxrep.2017.07.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Elena, Canzonieri Cristina, De Candia Salvatore, Tarascio Silvia, Giamporcaro Giovanni, Lumera Giuseppe, Rigano Carmela, Incognito Filippo, Privitera Agata, Guarnaccia Valerio, Foti Pietro Stefano, Palmucci Pietro, Gangemi Giulia, Fuccio-Sanzà Santo, Signorelli Salvatore A severe myopathy case in aged patient treated with high statin dosage |
title | A severe myopathy case in aged patient treated with high statin dosage |
title_full | A severe myopathy case in aged patient treated with high statin dosage |
title_fullStr | A severe myopathy case in aged patient treated with high statin dosage |
title_full_unstemmed | A severe myopathy case in aged patient treated with high statin dosage |
title_short | A severe myopathy case in aged patient treated with high statin dosage |
title_sort | severe myopathy case in aged patient treated with high statin dosage |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615159/ https://www.ncbi.nlm.nih.gov/pubmed/28959671 http://dx.doi.org/10.1016/j.toxrep.2017.07.009 |
work_keys_str_mv | AT elenacanzonieri aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT cristinadecandia aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT salvatoretarascio aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT silviagiamporcaro aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT giovannilumera aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT giusepperigano aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT carmelaincognito aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT filippoprivitera aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT agataguarnaccia aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT valeriofotipietro aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT stefanopalmucci aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT pietrogangemi aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT giuliafucciosanza aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT santosignorellisalvatore aseveremyopathycaseinagedpatienttreatedwithhighstatindosage AT elenacanzonieri severemyopathycaseinagedpatienttreatedwithhighstatindosage AT cristinadecandia severemyopathycaseinagedpatienttreatedwithhighstatindosage AT salvatoretarascio severemyopathycaseinagedpatienttreatedwithhighstatindosage AT silviagiamporcaro severemyopathycaseinagedpatienttreatedwithhighstatindosage AT giovannilumera severemyopathycaseinagedpatienttreatedwithhighstatindosage AT giusepperigano severemyopathycaseinagedpatienttreatedwithhighstatindosage AT carmelaincognito severemyopathycaseinagedpatienttreatedwithhighstatindosage AT filippoprivitera severemyopathycaseinagedpatienttreatedwithhighstatindosage AT agataguarnaccia severemyopathycaseinagedpatienttreatedwithhighstatindosage AT valeriofotipietro severemyopathycaseinagedpatienttreatedwithhighstatindosage AT stefanopalmucci severemyopathycaseinagedpatienttreatedwithhighstatindosage AT pietrogangemi severemyopathycaseinagedpatienttreatedwithhighstatindosage AT giuliafucciosanza severemyopathycaseinagedpatienttreatedwithhighstatindosage AT santosignorellisalvatore severemyopathycaseinagedpatienttreatedwithhighstatindosage |