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Taurine abated subacute dichlorvos toxicity
The aim of the study was to determine the effects of taurine in rats exposed to subacute dichlorvos toxicity. Fifty rats were weighed and assigned into five groups of ten rats each. The groups received: distilled water, soya oil (1 ml/kg), taurine (50 mg/kg), dichlorvos (10 mg/kg) and the combinatio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615161/ https://www.ncbi.nlm.nih.gov/pubmed/28959675 http://dx.doi.org/10.1016/j.toxrep.2017.08.001 |
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author | Akande, M.G. Ahmed, U.S. |
author_facet | Akande, M.G. Ahmed, U.S. |
author_sort | Akande, M.G. |
collection | PubMed |
description | The aim of the study was to determine the effects of taurine in rats exposed to subacute dichlorvos toxicity. Fifty rats were weighed and assigned into five groups of ten rats each. The groups received: distilled water, soya oil (1 ml/kg), taurine (50 mg/kg), dichlorvos (10 mg/kg) and the combination treatment group received taurine first and then dichlorvos 30 min later. The treatments were administered once daily by oral gavage for 4 weeks. The rats were euthanized and blood samples were collected after the termination of the study. Serum samples were analysed for malondialdehyde concentration and activities of antioxidant enzymes (superoxide dismutase and catalase). Dichlorvos increased malondialdehyde concentration and reduced the activities of superoxide dismutase and catalase. There was attenuation of malondialdehyde concentration and improvement of activities of superoxide dismutase (P = 0.0273) and catalase (P < 0.0001) in rats treated with taurine. It is postulated that taurine ameliorated dichlorvos-induced oxidative stress through the reduction of malondialdehyde concentration and the enhancement of activities of antioxidant enzymes. |
format | Online Article Text |
id | pubmed-5615161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56151612017-09-28 Taurine abated subacute dichlorvos toxicity Akande, M.G. Ahmed, U.S. Toxicol Rep Article The aim of the study was to determine the effects of taurine in rats exposed to subacute dichlorvos toxicity. Fifty rats were weighed and assigned into five groups of ten rats each. The groups received: distilled water, soya oil (1 ml/kg), taurine (50 mg/kg), dichlorvos (10 mg/kg) and the combination treatment group received taurine first and then dichlorvos 30 min later. The treatments were administered once daily by oral gavage for 4 weeks. The rats were euthanized and blood samples were collected after the termination of the study. Serum samples were analysed for malondialdehyde concentration and activities of antioxidant enzymes (superoxide dismutase and catalase). Dichlorvos increased malondialdehyde concentration and reduced the activities of superoxide dismutase and catalase. There was attenuation of malondialdehyde concentration and improvement of activities of superoxide dismutase (P = 0.0273) and catalase (P < 0.0001) in rats treated with taurine. It is postulated that taurine ameliorated dichlorvos-induced oxidative stress through the reduction of malondialdehyde concentration and the enhancement of activities of antioxidant enzymes. Elsevier 2017-08-30 /pmc/articles/PMC5615161/ /pubmed/28959675 http://dx.doi.org/10.1016/j.toxrep.2017.08.001 Text en © 2017 Published by Elsevier Ireland Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Akande, M.G. Ahmed, U.S. Taurine abated subacute dichlorvos toxicity |
title | Taurine abated subacute dichlorvos toxicity |
title_full | Taurine abated subacute dichlorvos toxicity |
title_fullStr | Taurine abated subacute dichlorvos toxicity |
title_full_unstemmed | Taurine abated subacute dichlorvos toxicity |
title_short | Taurine abated subacute dichlorvos toxicity |
title_sort | taurine abated subacute dichlorvos toxicity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615161/ https://www.ncbi.nlm.nih.gov/pubmed/28959675 http://dx.doi.org/10.1016/j.toxrep.2017.08.001 |
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