Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method

Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallo...

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Autores principales: Sairenji, Shiho, Kikuchi, Takashi, Abozeid, Mohamed Ahmed, Takizawa, Shinobu, Sasai, Hiroaki, Ando, Yuichiro, Ohmatsu, Kohsuke, Ooi, Takashi, Fujita, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615217/
https://www.ncbi.nlm.nih.gov/pubmed/28970900
http://dx.doi.org/10.1039/c7sc01524k
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author Sairenji, Shiho
Kikuchi, Takashi
Abozeid, Mohamed Ahmed
Takizawa, Shinobu
Sasai, Hiroaki
Ando, Yuichiro
Ohmatsu, Kohsuke
Ooi, Takashi
Fujita, Makoto
author_facet Sairenji, Shiho
Kikuchi, Takashi
Abozeid, Mohamed Ahmed
Takizawa, Shinobu
Sasai, Hiroaki
Ando, Yuichiro
Ohmatsu, Kohsuke
Ooi, Takashi
Fujita, Makoto
author_sort Sairenji, Shiho
collection PubMed
description Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions.
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spelling pubmed-56152172017-10-02 Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method Sairenji, Shiho Kikuchi, Takashi Abozeid, Mohamed Ahmed Takizawa, Shinobu Sasai, Hiroaki Ando, Yuichiro Ohmatsu, Kohsuke Ooi, Takashi Fujita, Makoto Chem Sci Chemistry Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions. Royal Society of Chemistry 2017-07-01 2017-05-16 /pmc/articles/PMC5615217/ /pubmed/28970900 http://dx.doi.org/10.1039/c7sc01524k Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Sairenji, Shiho
Kikuchi, Takashi
Abozeid, Mohamed Ahmed
Takizawa, Shinobu
Sasai, Hiroaki
Ando, Yuichiro
Ohmatsu, Kohsuke
Ooi, Takashi
Fujita, Makoto
Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title_full Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title_fullStr Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title_full_unstemmed Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title_short Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
title_sort determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615217/
https://www.ncbi.nlm.nih.gov/pubmed/28970900
http://dx.doi.org/10.1039/c7sc01524k
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