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Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits

Keratin-associated proteins (KAPs) are structural components of wool and hair fibres, and are believed to play a role in defining the physico-mechanical properties of the wool fibre. In this study, the putative ovine homologue of the human KAP26-1 gene (KRTAP26-1) was sequenced and four variants (na...

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Autores principales: Li, Shaobin, Zhou, Huitong, Gong, Hua, Zhao, Fangfang, Hu, Jiang, Luo, Yuzhu, Hickford, Jon G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615358/
https://www.ncbi.nlm.nih.gov/pubmed/28902131
http://dx.doi.org/10.3390/genes8090225
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author Li, Shaobin
Zhou, Huitong
Gong, Hua
Zhao, Fangfang
Hu, Jiang
Luo, Yuzhu
Hickford, Jon G. H.
author_facet Li, Shaobin
Zhou, Huitong
Gong, Hua
Zhao, Fangfang
Hu, Jiang
Luo, Yuzhu
Hickford, Jon G. H.
author_sort Li, Shaobin
collection PubMed
description Keratin-associated proteins (KAPs) are structural components of wool and hair fibres, and are believed to play a role in defining the physico-mechanical properties of the wool fibre. In this study, the putative ovine homologue of the human KAP26-1 gene (KRTAP26-1) was sequenced and four variants (named A–D) were identified. The sequences shared some identity with each other and with other KRTAPs, but they had the greatest similarity with the human KRTAP26-1 sequence. This suggests they represent different variants of ovine KRTAP26-1. The association of these KRTAP26-1 variants with wool traits was investigated in the 383 Merino-Southdown cross sheep. The presence of B was associated (p < 0.05) with an increase in mean fibre diameter (MFD), mean fibre curvature, and prickle factor (PF). The presence of C was found to be associated (p < 0.05) with an increase in wool yield (Yield) and mean staple length (MSL), and a decrease in MFD, fibre diameter standard deviation (FDSD), and PF. The results suggest that sheep with C have, on average, higher wool quality. These results may be useful in the future development of breeding programs based on decreasing wool MFD and FDSD, or on increasing wool MSL.
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spelling pubmed-56153582017-09-28 Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Li, Shaobin Zhou, Huitong Gong, Hua Zhao, Fangfang Hu, Jiang Luo, Yuzhu Hickford, Jon G. H. Genes (Basel) Article Keratin-associated proteins (KAPs) are structural components of wool and hair fibres, and are believed to play a role in defining the physico-mechanical properties of the wool fibre. In this study, the putative ovine homologue of the human KAP26-1 gene (KRTAP26-1) was sequenced and four variants (named A–D) were identified. The sequences shared some identity with each other and with other KRTAPs, but they had the greatest similarity with the human KRTAP26-1 sequence. This suggests they represent different variants of ovine KRTAP26-1. The association of these KRTAP26-1 variants with wool traits was investigated in the 383 Merino-Southdown cross sheep. The presence of B was associated (p < 0.05) with an increase in mean fibre diameter (MFD), mean fibre curvature, and prickle factor (PF). The presence of C was found to be associated (p < 0.05) with an increase in wool yield (Yield) and mean staple length (MSL), and a decrease in MFD, fibre diameter standard deviation (FDSD), and PF. The results suggest that sheep with C have, on average, higher wool quality. These results may be useful in the future development of breeding programs based on decreasing wool MFD and FDSD, or on increasing wool MSL. MDPI 2017-09-13 /pmc/articles/PMC5615358/ /pubmed/28902131 http://dx.doi.org/10.3390/genes8090225 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Shaobin
Zhou, Huitong
Gong, Hua
Zhao, Fangfang
Hu, Jiang
Luo, Yuzhu
Hickford, Jon G. H.
Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title_full Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title_fullStr Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title_full_unstemmed Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title_short Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
title_sort identification of the ovine keratin-associated protein 26-1 gene and its association with variation in wool traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615358/
https://www.ncbi.nlm.nih.gov/pubmed/28902131
http://dx.doi.org/10.3390/genes8090225
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