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Satellite DNA: An Evolving Topic

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution...

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Autor principal: Garrido-Ramos, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615363/
https://www.ncbi.nlm.nih.gov/pubmed/28926993
http://dx.doi.org/10.3390/genes8090230
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author Garrido-Ramos, Manuel A.
author_facet Garrido-Ramos, Manuel A.
author_sort Garrido-Ramos, Manuel A.
collection PubMed
description Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution.
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spelling pubmed-56153632017-09-28 Satellite DNA: An Evolving Topic Garrido-Ramos, Manuel A. Genes (Basel) Review Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution. MDPI 2017-09-18 /pmc/articles/PMC5615363/ /pubmed/28926993 http://dx.doi.org/10.3390/genes8090230 Text en © 2017 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garrido-Ramos, Manuel A.
Satellite DNA: An Evolving Topic
title Satellite DNA: An Evolving Topic
title_full Satellite DNA: An Evolving Topic
title_fullStr Satellite DNA: An Evolving Topic
title_full_unstemmed Satellite DNA: An Evolving Topic
title_short Satellite DNA: An Evolving Topic
title_sort satellite dna: an evolving topic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615363/
https://www.ncbi.nlm.nih.gov/pubmed/28926993
http://dx.doi.org/10.3390/genes8090230
work_keys_str_mv AT garridoramosmanuela satellitednaanevolvingtopic