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Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal

This study aimed to describe lipid profiles and the distribution of glycated hemoglobin (HbA1c) in a sample of a high altitude population of Nepal and to explore associations between these metabolic risk variables and altitude. A cross-sectional survey of cardiovascular disease and associated risk f...

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Autores principales: Aryal, Nirmal, Weatherall, Mark, Bhatta, Yadav Kumar Deo, Mann, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615578/
https://www.ncbi.nlm.nih.gov/pubmed/28891952
http://dx.doi.org/10.3390/ijerph14091041
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author Aryal, Nirmal
Weatherall, Mark
Bhatta, Yadav Kumar Deo
Mann, Stewart
author_facet Aryal, Nirmal
Weatherall, Mark
Bhatta, Yadav Kumar Deo
Mann, Stewart
author_sort Aryal, Nirmal
collection PubMed
description This study aimed to describe lipid profiles and the distribution of glycated hemoglobin (HbA1c) in a sample of a high altitude population of Nepal and to explore associations between these metabolic risk variables and altitude. A cross-sectional survey of cardiovascular disease and associated risk factors was conducted among 521 people living at four different altitude levels, all above 2800 m, in the Mustang and Humla districts of Nepal. Urban participants (residents at 2800 m and 3620 m) had higher total cholesterol (TC) and triglyceride (TG) than rural participants. A high ratio of TC to high-density lipoprotein-cholesterol (HDL) (TC/HDL ≥ 5.0) was found in 23.7% (95% CI 19.6, 28.2) and high TG (≥1.7 mmol/L) in 43.3% (95% CI 38.4, 48.3) of participants overall. Mean HbA1c levels were similar at all altitude levels although urban participants had a higher prevalence of diabetes. Overall, 6.9% (95% CI 4.7, 9.8) of participants had diabetes or were on hypoglycaemic treatment. There was no clear association between lipid profiles or HbA1c and altitude in a multivariate analysis adjusted for possible confounding variables. Residential settings and associated lifestyle practices are more strongly associated with lipid profiles and HbA1c than altitude amongst high altitude residents in Nepal.
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spelling pubmed-56155782017-09-30 Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal Aryal, Nirmal Weatherall, Mark Bhatta, Yadav Kumar Deo Mann, Stewart Int J Environ Res Public Health Article This study aimed to describe lipid profiles and the distribution of glycated hemoglobin (HbA1c) in a sample of a high altitude population of Nepal and to explore associations between these metabolic risk variables and altitude. A cross-sectional survey of cardiovascular disease and associated risk factors was conducted among 521 people living at four different altitude levels, all above 2800 m, in the Mustang and Humla districts of Nepal. Urban participants (residents at 2800 m and 3620 m) had higher total cholesterol (TC) and triglyceride (TG) than rural participants. A high ratio of TC to high-density lipoprotein-cholesterol (HDL) (TC/HDL ≥ 5.0) was found in 23.7% (95% CI 19.6, 28.2) and high TG (≥1.7 mmol/L) in 43.3% (95% CI 38.4, 48.3) of participants overall. Mean HbA1c levels were similar at all altitude levels although urban participants had a higher prevalence of diabetes. Overall, 6.9% (95% CI 4.7, 9.8) of participants had diabetes or were on hypoglycaemic treatment. There was no clear association between lipid profiles or HbA1c and altitude in a multivariate analysis adjusted for possible confounding variables. Residential settings and associated lifestyle practices are more strongly associated with lipid profiles and HbA1c than altitude amongst high altitude residents in Nepal. MDPI 2017-09-10 2017-09 /pmc/articles/PMC5615578/ /pubmed/28891952 http://dx.doi.org/10.3390/ijerph14091041 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aryal, Nirmal
Weatherall, Mark
Bhatta, Yadav Kumar Deo
Mann, Stewart
Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title_full Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title_fullStr Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title_full_unstemmed Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title_short Lipid Profiles, Glycated Hemoglobin, and Diabetes in People Living at High Altitude in Nepal
title_sort lipid profiles, glycated hemoglobin, and diabetes in people living at high altitude in nepal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615578/
https://www.ncbi.nlm.nih.gov/pubmed/28891952
http://dx.doi.org/10.3390/ijerph14091041
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