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Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain
Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615596/ https://www.ncbi.nlm.nih.gov/pubmed/28902174 http://dx.doi.org/10.3390/ijerph14091059 |
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author | van der Meer, Thomas P. Artacho-Cordón, Francisco Swaab, Dick F. Struik, Dicky Makris, Konstantinos C. Wolffenbuttel, Bruce H. R. Frederiksen, Hanne van Vliet-Ostaptchouk, Jana V. |
author_facet | van der Meer, Thomas P. Artacho-Cordón, Francisco Swaab, Dick F. Struik, Dicky Makris, Konstantinos C. Wolffenbuttel, Bruce H. R. Frederiksen, Hanne van Vliet-Ostaptchouk, Jana V. |
author_sort | van der Meer, Thomas P. |
collection | PubMed |
description | Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m(2), respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood–brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated. |
format | Online Article Text |
id | pubmed-5615596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56155962017-09-30 Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain van der Meer, Thomas P. Artacho-Cordón, Francisco Swaab, Dick F. Struik, Dicky Makris, Konstantinos C. Wolffenbuttel, Bruce H. R. Frederiksen, Hanne van Vliet-Ostaptchouk, Jana V. Int J Environ Res Public Health Brief Report Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m(2), respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood–brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated. MDPI 2017-09-13 2017-09 /pmc/articles/PMC5615596/ /pubmed/28902174 http://dx.doi.org/10.3390/ijerph14091059 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report van der Meer, Thomas P. Artacho-Cordón, Francisco Swaab, Dick F. Struik, Dicky Makris, Konstantinos C. Wolffenbuttel, Bruce H. R. Frederiksen, Hanne van Vliet-Ostaptchouk, Jana V. Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title | Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title_full | Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title_fullStr | Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title_full_unstemmed | Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title_short | Distribution of Non-Persistent Endocrine Disruptors in Two Different Regions of the Human Brain |
title_sort | distribution of non-persistent endocrine disruptors in two different regions of the human brain |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615596/ https://www.ncbi.nlm.nih.gov/pubmed/28902174 http://dx.doi.org/10.3390/ijerph14091059 |
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