Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia

We describe an unusual case of a biclonal nodal plasma cell dyscrasia, presenting with a vasculitic rash, end-organ damage, and cytopenias. Serum protein electrophoresis demonstrated a biclonal kappa-restricted paraprotein, with a negative skeletal survey and no bone marrow disease. Fluorodeoxygluco...

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Detalles Bibliográficos
Autores principales: Swan, D., Murphy, M., Elhassadi, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615981/
https://www.ncbi.nlm.nih.gov/pubmed/29057130
http://dx.doi.org/10.1155/2017/8152610
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author Swan, D.
Murphy, M.
Elhassadi, E.
author_facet Swan, D.
Murphy, M.
Elhassadi, E.
author_sort Swan, D.
collection PubMed
description We describe an unusual case of a biclonal nodal plasma cell dyscrasia, presenting with a vasculitic rash, end-organ damage, and cytopenias. Serum protein electrophoresis demonstrated a biclonal kappa-restricted paraprotein, with a negative skeletal survey and no bone marrow disease. Fluorodeoxyglucose-PET-CT (FDG-PET-CT) revealed nodal involvement, which was not appreciable clinically, and facilitated biopsy, confirming the diagnosis of a nodal plasmacytoma. Complete biochemical response and resolution of the vasculitic rash were achieved with bortezomib-based therapy.
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spelling pubmed-56159812017-10-22 Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia Swan, D. Murphy, M. Elhassadi, E. Case Rep Hematol Case Report We describe an unusual case of a biclonal nodal plasma cell dyscrasia, presenting with a vasculitic rash, end-organ damage, and cytopenias. Serum protein electrophoresis demonstrated a biclonal kappa-restricted paraprotein, with a negative skeletal survey and no bone marrow disease. Fluorodeoxyglucose-PET-CT (FDG-PET-CT) revealed nodal involvement, which was not appreciable clinically, and facilitated biopsy, confirming the diagnosis of a nodal plasmacytoma. Complete biochemical response and resolution of the vasculitic rash were achieved with bortezomib-based therapy. Hindawi 2017 2017-09-13 /pmc/articles/PMC5615981/ /pubmed/29057130 http://dx.doi.org/10.1155/2017/8152610 Text en Copyright © 2017 D. Swan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Swan, D.
Murphy, M.
Elhassadi, E.
Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title_full Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title_fullStr Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title_full_unstemmed Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title_short Cutaneous Vasculitis: An Unusual Presentation of a Biclonal Nodal Plasma Cell Dyscrasia
title_sort cutaneous vasculitis: an unusual presentation of a biclonal nodal plasma cell dyscrasia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615981/
https://www.ncbi.nlm.nih.gov/pubmed/29057130
http://dx.doi.org/10.1155/2017/8152610
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AT murphym cutaneousvasculitisanunusualpresentationofabiclonalnodalplasmacelldyscrasia
AT elhassadie cutaneousvasculitisanunusualpresentationofabiclonalnodalplasmacelldyscrasia

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