Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions

Calcium ions bind at the gating ring which triggers the gating of BK channels. However, the allosteric mechanism by which Ca(2+) regulates the gating of BK channels remains obscure. Here, we applied Molecular Dynamics (MD) and Targeted MD to the integrated gating ring of BK channels, and achieved th...

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Detalles Bibliográficos
Autores principales: Guan, Ronghua, Zhou, Hui, Li, Junwei, Xiao, Shaoying, Pang, Chunli, Chen, Yafei, Du, Xiangrong, Ke, Shaoxi, Tang, Qiongyao, Su, Jiguo, Zhan, Yong, An, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://www.ncbi.nlm.nih.gov/pubmed/28953901
http://dx.doi.org/10.1371/journal.pone.0182067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617150/
https://www.ncbi.nlm.nih.gov/pubmed/28953901
http://dx.doi.org/10.1371/journal.pone.0182067

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