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DNA replication stress restricts ribosomal DNA copy number

Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100–200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the i...

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Detalles Bibliográficos
Autores principales:	Salim, Devika, Bradford, William D., Freeland, Amy, Cady, Gillian, Wang, Jianmin, Pruitt, Steven C., Gerton, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617229/ https://www.ncbi.nlm.nih.gov/pubmed/28915237 http://dx.doi.org/10.1371/journal.pgen.1007006

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