Autophagy-related gene expression is an independent prognostic indicator of glioma

In this study, we identified 74 differentially expressed autophagy-related genes in glioma patients. Analysis using a Cox proportional hazard regression model showed that MAPK8IP1 and SH3GLB1, two autophagy-related genes, were associated with the prognostic signature for glioma. Glioma patients from...

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Autores principales: Zhang, Huixue, Lu, Xiaoyan, Wang, Ning, Wang, Jianjian, Cao, Yuze, Wang, Tianfeng, Zhou, Xueling, Jiao, Yang, Yang, Lei, Wang, Xiaokun, Cong, Lin, Li, Jianlong, Li, Jie, Ma, He-Ping, Pan, Yonghui, Ning, Shangwei, Wang, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617400/
https://www.ncbi.nlm.nih.gov/pubmed/28977840
http://dx.doi.org/10.18632/oncotarget.17719
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author Zhang, Huixue
Lu, Xiaoyan
Wang, Ning
Wang, Jianjian
Cao, Yuze
Wang, Tianfeng
Zhou, Xueling
Jiao, Yang
Yang, Lei
Wang, Xiaokun
Cong, Lin
Li, Jianlong
Li, Jie
Ma, He-Ping
Pan, Yonghui
Ning, Shangwei
Wang, Lihua
author_facet Zhang, Huixue
Lu, Xiaoyan
Wang, Ning
Wang, Jianjian
Cao, Yuze
Wang, Tianfeng
Zhou, Xueling
Jiao, Yang
Yang, Lei
Wang, Xiaokun
Cong, Lin
Li, Jianlong
Li, Jie
Ma, He-Ping
Pan, Yonghui
Ning, Shangwei
Wang, Lihua
author_sort Zhang, Huixue
collection PubMed
description In this study, we identified 74 differentially expressed autophagy-related genes in glioma patients. Analysis using a Cox proportional hazard regression model showed that MAPK8IP1 and SH3GLB1, two autophagy-related genes, were associated with the prognostic signature for glioma. Glioma patients from the CGGA batches 1 and 2, GSE4412 and TCGA datasets could be divided into high- and low-risk groups with different survival times based on levels of MAPK8IP1 and SH3GLB1 expression. The autophagy-related signature was an independent predictor of survival outcomes in glioma patients. MAPK8IP1 overexpression and SH3GLB1 knockdown inhibited glioma cell proliferation, migration and invasion, and improved Temozolomide sensitivity. These findings suggest autophagy-related genes like MAPK8IP1 and SH3GLB1 could be potential therapeutic targets in glioma.
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spelling pubmed-56174002017-10-03 Autophagy-related gene expression is an independent prognostic indicator of glioma Zhang, Huixue Lu, Xiaoyan Wang, Ning Wang, Jianjian Cao, Yuze Wang, Tianfeng Zhou, Xueling Jiao, Yang Yang, Lei Wang, Xiaokun Cong, Lin Li, Jianlong Li, Jie Ma, He-Ping Pan, Yonghui Ning, Shangwei Wang, Lihua Oncotarget Research Paper In this study, we identified 74 differentially expressed autophagy-related genes in glioma patients. Analysis using a Cox proportional hazard regression model showed that MAPK8IP1 and SH3GLB1, two autophagy-related genes, were associated with the prognostic signature for glioma. Glioma patients from the CGGA batches 1 and 2, GSE4412 and TCGA datasets could be divided into high- and low-risk groups with different survival times based on levels of MAPK8IP1 and SH3GLB1 expression. The autophagy-related signature was an independent predictor of survival outcomes in glioma patients. MAPK8IP1 overexpression and SH3GLB1 knockdown inhibited glioma cell proliferation, migration and invasion, and improved Temozolomide sensitivity. These findings suggest autophagy-related genes like MAPK8IP1 and SH3GLB1 could be potential therapeutic targets in glioma. Impact Journals LLC 2017-05-09 /pmc/articles/PMC5617400/ /pubmed/28977840 http://dx.doi.org/10.18632/oncotarget.17719 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Huixue
Lu, Xiaoyan
Wang, Ning
Wang, Jianjian
Cao, Yuze
Wang, Tianfeng
Zhou, Xueling
Jiao, Yang
Yang, Lei
Wang, Xiaokun
Cong, Lin
Li, Jianlong
Li, Jie
Ma, He-Ping
Pan, Yonghui
Ning, Shangwei
Wang, Lihua
Autophagy-related gene expression is an independent prognostic indicator of glioma
title Autophagy-related gene expression is an independent prognostic indicator of glioma
title_full Autophagy-related gene expression is an independent prognostic indicator of glioma
title_fullStr Autophagy-related gene expression is an independent prognostic indicator of glioma
title_full_unstemmed Autophagy-related gene expression is an independent prognostic indicator of glioma
title_short Autophagy-related gene expression is an independent prognostic indicator of glioma
title_sort autophagy-related gene expression is an independent prognostic indicator of glioma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617400/
https://www.ncbi.nlm.nih.gov/pubmed/28977840
http://dx.doi.org/10.18632/oncotarget.17719
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