Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy

Cervical carcinoma is one of the main causes of women’s cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could in...

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Detalles Bibliográficos
Autores principales: Xia, Leilei, Wang, Ye, Chen, Ya, Yan, Jiuqiong, Hao, Fan, Su, Xiaoling, Zhang, Caihong, Xu, Mingjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617408/
https://www.ncbi.nlm.nih.gov/pubmed/28977848
http://dx.doi.org/10.18632/oncotarget.17854
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author Xia, Leilei
Wang, Ye
Chen, Ya
Yan, Jiuqiong
Hao, Fan
Su, Xiaoling
Zhang, Caihong
Xu, Mingjuan
author_facet Xia, Leilei
Wang, Ye
Chen, Ya
Yan, Jiuqiong
Hao, Fan
Su, Xiaoling
Zhang, Caihong
Xu, Mingjuan
author_sort Xia, Leilei
collection PubMed
description Cervical carcinoma is one of the main causes of women’s cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo. Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications.
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spelling pubmed-56174082017-10-03 Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy Xia, Leilei Wang, Ye Chen, Ya Yan, Jiuqiong Hao, Fan Su, Xiaoling Zhang, Caihong Xu, Mingjuan Oncotarget Research Paper Cervical carcinoma is one of the main causes of women’s cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo. Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications. Impact Journals LLC 2017-05-15 /pmc/articles/PMC5617408/ /pubmed/28977848 http://dx.doi.org/10.18632/oncotarget.17854 Text en Copyright: © 2017 Xia et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xia, Leilei
Wang, Ye
Chen, Ya
Yan, Jiuqiong
Hao, Fan
Su, Xiaoling
Zhang, Caihong
Xu, Mingjuan
Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title_full Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title_fullStr Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title_full_unstemmed Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title_short Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
title_sort cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617408/
https://www.ncbi.nlm.nih.gov/pubmed/28977848
http://dx.doi.org/10.18632/oncotarget.17854
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