Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury

This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein a...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Xu, Jian, Zhao, Jian, Chen, Yuzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617431/
https://www.ncbi.nlm.nih.gov/pubmed/28977871
http://dx.doi.org/10.18632/oncotarget.18219
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author Zhang, Rui
Xu, Jian
Zhao, Jian
Chen, Yuzhe
author_facet Zhang, Rui
Xu, Jian
Zhao, Jian
Chen, Yuzhe
author_sort Zhang, Rui
collection PubMed
description This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ratio. Meanwhile, genistein reduced colonic inflammatory response via downregulating cytokines expression and improved colonic permeability and barrier in DSS-challenged mice. In Caco-2 cells, genistein improved cell viability and cellular permeability and inhibited DSS-induced activation of TLR4/NF-κB signal. In conclusion, genistein alleviated DSS-caused colonic injury, inflammation, and gut dysfunction, which might be associated with the TLR4/NF-κB signal.
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spelling pubmed-56174312017-10-03 Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury Zhang, Rui Xu, Jian Zhao, Jian Chen, Yuzhe Oncotarget Research Paper This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ratio. Meanwhile, genistein reduced colonic inflammatory response via downregulating cytokines expression and improved colonic permeability and barrier in DSS-challenged mice. In Caco-2 cells, genistein improved cell viability and cellular permeability and inhibited DSS-induced activation of TLR4/NF-κB signal. In conclusion, genistein alleviated DSS-caused colonic injury, inflammation, and gut dysfunction, which might be associated with the TLR4/NF-κB signal. Impact Journals LLC 2017-05-26 /pmc/articles/PMC5617431/ /pubmed/28977871 http://dx.doi.org/10.18632/oncotarget.18219 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Rui
Xu, Jian
Zhao, Jian
Chen, Yuzhe
Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title_full Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title_fullStr Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title_full_unstemmed Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title_short Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury
title_sort genistein improves inflammatory response and colonic function through nf-κb signal in dss-induced colonic injury
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617431/
https://www.ncbi.nlm.nih.gov/pubmed/28977871
http://dx.doi.org/10.18632/oncotarget.18219
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AT zhaojian genisteinimprovesinflammatoryresponseandcolonicfunctionthroughnfkbsignalindssinducedcolonicinjury
AT chenyuzhe genisteinimprovesinflammatoryresponseandcolonicfunctionthroughnfkbsignalindssinducedcolonicinjury

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