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Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer
OBJECTIVE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and Februar...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617433/ https://www.ncbi.nlm.nih.gov/pubmed/28977873 http://dx.doi.org/10.18632/oncotarget.18248 |
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author | Hamano, Itsuto Hatakeyama, Shingo Iwamurau, Hiromichi Fujita, Naoki Fukushi, Ken Narita, Takuma Hagiwara, Kazuhisa Kusaka, Ayumu Hosogoe, Shogo Yamamoto, Hayato Tobisawa, Yuki Yoneyama, Tohru Yoneyama, Takahiro Hashimoto, Yasuhiro Koie, Takuya Ito, Hiroyuki Yoshikawa, Kazuaki Kawaguchi, Toshiaki Ohyama, Chikara |
author_facet | Hamano, Itsuto Hatakeyama, Shingo Iwamurau, Hiromichi Fujita, Naoki Fukushi, Ken Narita, Takuma Hagiwara, Kazuhisa Kusaka, Ayumu Hosogoe, Shogo Yamamoto, Hayato Tobisawa, Yuki Yoneyama, Tohru Yoneyama, Takahiro Hashimoto, Yasuhiro Koie, Takuya Ito, Hiroyuki Yoshikawa, Kazuaki Kawaguchi, Toshiaki Ohyama, Chikara |
author_sort | Hamano, Itsuto |
collection | PubMed |
description | OBJECTIVE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs. non-CKD). We performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) to evaluate the impact of preoperative CKD on prognosis and developed the prognostic factor-based risk stratification nomogram RESULTS: Of the 581 patients, 215 (37%) were diagnosed with CKD before radical cystectomy. Before the background adjustment, PFS, CSS, and OS after radical cystectomy were significantly lower in the pre-CKD group compared to the non-CKD group. Background-adjusted IPTW analysis showed that preoperative CKD was significantly associated with poor PFS, CSS, and OS after radical cystectomy. The nomogram for predicting 5-year PFS and OS probability showed significant correlation with actual PFS and OS (c-index = 0.73 and 0.77, respectively). CONCLUSIONS: Muscle-invasive bladder cancer patients with preoperative CKD had a significantly lower survival probability than those without CKD. |
format | Online Article Text |
id | pubmed-5617433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56174332017-10-03 Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer Hamano, Itsuto Hatakeyama, Shingo Iwamurau, Hiromichi Fujita, Naoki Fukushi, Ken Narita, Takuma Hagiwara, Kazuhisa Kusaka, Ayumu Hosogoe, Shogo Yamamoto, Hayato Tobisawa, Yuki Yoneyama, Tohru Yoneyama, Takahiro Hashimoto, Yasuhiro Koie, Takuya Ito, Hiroyuki Yoshikawa, Kazuaki Kawaguchi, Toshiaki Ohyama, Chikara Oncotarget Research Paper OBJECTIVE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs. non-CKD). We performed a Cox proportional hazards regression analysis using inverse probability of treatment weighting (IPTW) to evaluate the impact of preoperative CKD on prognosis and developed the prognostic factor-based risk stratification nomogram RESULTS: Of the 581 patients, 215 (37%) were diagnosed with CKD before radical cystectomy. Before the background adjustment, PFS, CSS, and OS after radical cystectomy were significantly lower in the pre-CKD group compared to the non-CKD group. Background-adjusted IPTW analysis showed that preoperative CKD was significantly associated with poor PFS, CSS, and OS after radical cystectomy. The nomogram for predicting 5-year PFS and OS probability showed significant correlation with actual PFS and OS (c-index = 0.73 and 0.77, respectively). CONCLUSIONS: Muscle-invasive bladder cancer patients with preoperative CKD had a significantly lower survival probability than those without CKD. Impact Journals LLC 2017-05-29 /pmc/articles/PMC5617433/ /pubmed/28977873 http://dx.doi.org/10.18632/oncotarget.18248 Text en Copyright: © 2017 Hamano et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hamano, Itsuto Hatakeyama, Shingo Iwamurau, Hiromichi Fujita, Naoki Fukushi, Ken Narita, Takuma Hagiwara, Kazuhisa Kusaka, Ayumu Hosogoe, Shogo Yamamoto, Hayato Tobisawa, Yuki Yoneyama, Tohru Yoneyama, Takahiro Hashimoto, Yasuhiro Koie, Takuya Ito, Hiroyuki Yoshikawa, Kazuaki Kawaguchi, Toshiaki Ohyama, Chikara Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title_full | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title_fullStr | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title_full_unstemmed | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title_short | Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
title_sort | preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617433/ https://www.ncbi.nlm.nih.gov/pubmed/28977873 http://dx.doi.org/10.18632/oncotarget.18248 |
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