Expression of LAG-3 defines exhaustion of intratumoral PD-1(+) T cells and correlates with poor outcome in follicular lymphoma

Exhausted T-cells in follicular lymphoma (FL) typically express PD-1, but expression of PD-1 is not limited to exhausted cells. Although expected to be functionally suppressed, we found that the population of intratumoral PD-1(+) T cells were predominantly responsible for production of cytokines and...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Zhi-Zhang, Kim, Hyo Jin, Villasboas, Jose C., Chen, Ya-Ping, Price-Troska, Tammy, Jalali, Shahrzad, Wilson, Mara, Novak, Anne J., Ansell, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617435/
https://www.ncbi.nlm.nih.gov/pubmed/28977875
http://dx.doi.org/10.18632/oncotarget.18251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617435/
https://www.ncbi.nlm.nih.gov/pubmed/28977875
http://dx.doi.org/10.18632/oncotarget.18251

Ejemplares similares