ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways

Cutaneous T-cell lymphomas (CTCLs) are extremely symptomatic and still incurable, and more effective and less toxic therapies are urgently needed. ONC201, an imipridone compound, has shown efficacy in pre-clinical studies in multiple advanced cancers. This study was to evaluate the anti-tumor activi...

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Detalles Bibliográficos
Autores principales: Ni, Xiao, Zhang, Xiang, Hu, Cheng-Hui, Langridge, Timothy, Tarapore, Rohinton S., Allen, Joshua E., Oster, Wolfgang, Duvic, Madeleine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617462/
https://www.ncbi.nlm.nih.gov/pubmed/28977902
http://dx.doi.org/10.18632/oncotarget.18688

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