Cargando…

Integrated analysis of somatic mutations and immune microenvironment of multiple regions in breast cancers

Next-generation sequencing technology enables us to analyze the complexity of intra- and inter-tumoral heterogeneity, which may influence to prognosis of cancer patients. In this study, we collected surgically-resected tumor tissues from five breast cancer patients and characterized three different...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kato, Taigo, Park, Jae-Hyun, Kiyotani, Kazuma, Ikeda, Yuji, Miyoshi, Yasuo, Nakamura, Yusuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617483/ https://www.ncbi.nlm.nih.gov/pubmed/28977923 http://dx.doi.org/10.18632/oncotarget.18790

Ejemplares similares

Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells
por: Kato, Taigo, et al.
Publicado: (2018)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

Similarity and difference in tumor-infiltrating lymphocytes in original tumor tissues and those of in vitro expanded populations in head and neck cancer
por: Ren, Lili, et al.
Publicado: (2017)

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma
por: Ren, Lili, et al.
Publicado: (2019)

Genomic and Pathological Characterization of Multiple Renal Cell Carcinoma Regions in Patient With Tuberous Sclerosis Complex: A Case Report
por: Yamamoto, Tetsuya, et al.
Publicado: (2021)

Personalized immunotherapy in cancer precision medicine
por: Kiyotani, Kazuma, et al.
Publicado: (2021)

Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer
por: Ikeda, Yuji, et al.
Publicado: (2017)

CD8 lymphocytes in tumors and nonsynonymous mutational load correlate with prognosis of bladder cancer patients treated with immune checkpoint inhibitors
por: Deng, Boya, et al.
Publicado: (2018)

Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens
por: Kiyotani, Kazuma, et al.
Publicado: (2018)

Comparison of exome-based HLA class I genotyping tools: identification of platform-specific genotyping errors
por: Kiyotani, Kazuma, et al.
Publicado: (2017)

Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2
por: Kiyotani, Kazuma, et al.
Publicado: (2020)

Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3
por: Tate, Tomohiro, et al.
Publicado: (2023)

Precision Medicine for Colorectal Cancer with Liquid Biopsy and Immunotherapy
por: Nagayama, Satoshi, et al.
Publicado: (2021)

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer
por: Melo, Camila Morais, et al.
Publicado: (2021)

SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
por: Toyoshima, Yujiro, et al.
Publicado: (2020)

A pilot study of durvalumab and tremelimumab and immunogenomic dynamics in metastatic breast cancer
por: Santa-Maria, Cesar August, et al.
Publicado: (2018)

Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy
por: Okamura, Kazumi, et al.
Publicado: (2022)

WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck
por: Saloura, Vassiliki, et al.
Publicado: (2016)

Somatic mutation in noncoding regions: The sound of silence
por: Tan, Hua
Publicado: (2020)

Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors
por: Nakakido, Makoto, et al.
Publicado: (2016)

Morphological Changes, Cadherin Switching, and Growth Suppression in Pancreatic Cancer by GALNT6 Knockdown()
por: Tarhan, Yunus Emre, et al.
Publicado: (2016)

Significant differences in T cell receptor repertoires in lung adenocarcinomas with and without epidermal growth factor receptor mutations
por: Miyauchi, Eisaku, et al.
Publicado: (2019)

Immunoglobulin profiling identifies unique signatures in patients with Kawasaki disease during intravenous immunoglobulin treatment
por: Ko, Tai-Ming, et al.
Publicado: (2018)

Multiplicity: an organizing principle for cancers and somatic mutations
por: Frey, Lewis J, et al.
Publicado: (2011)

Novel genetic linkage of rat Sp6 mutation to Amelogenesis imperfecta
por: Muto, Taro, et al.
Publicado: (2012)

Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells
por: Kato, Taigo, et al.
Publicado: (2016)

TOPK (T‐LAK cell‐originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer
por: Park, Jae‐Hyun, et al.
Publicado: (2017)

Infrequent Somatic Mutation of the MTS1 Gene in Primary Bladder Carcinomas
por: Kai, Mikio, et al.
Publicado: (1995)

Highly clonal regulatory T-cell population in follicular lymphoma – inverse correlation with the diversity of CD8(+) T cells
por: Liu, Xiao, et al.
Publicado: (2015)

Integrative Analysis of Somatic Mutations in Non-coding Regions Altering RNA Secondary Structures in Cancer Genomes
por: He, Funan, et al.
Publicado: (2019)

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia
por: Wang, Yaping, et al.
Publicado: (2022)

Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
por: Ishino, Takamasa, et al.
Publicado: (2023)

Combining calls from multiple somatic mutation-callers
por: Kim, Su Yeon, et al.
Publicado: (2014)

Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data
por: Jiang, Ying, et al.
Publicado: (2021)

The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation
por: Horiguchi, Taigo, et al.
Publicado: (2022)

WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer
por: Saloura, Vassiliki, et al.
Publicado: (2017)

Neoantigens elicit T cell responses in breast cancer
por: Morisaki, Takafumi, et al.
Publicado: (2021)

Recurrent Somatic Mutations in Regulatory Regions of Human Cancer Genomes
por: Melton, Collin, et al.
Publicado: (2015)

Predicting regional somatic mutation rates using DNA motifs
por: Liu, Cong, et al.
Publicado: (2023)

Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinoma
por: Kato, Taigo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_22i15elijrqspfcu37i9sajkvi