Cargando…
Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients
LncRNA GAS5 plays a tumor suppressive role in a variety of human cancers and promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. However, the role of GAS5 in nasopharyngeal carcinoma (NPC) remains elusive. The objective of the present study was to evaluate t...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617505/ https://www.ncbi.nlm.nih.gov/pubmed/28977945 http://dx.doi.org/10.18632/oncotarget.19725 |
_version_ | 1783267003189952512 |
---|---|
author | Guo, Zhen Wang, Youhong Zhao, Yu Jin, Yi An, Liang Wu, Bin Liu, Zhaoqian Chen, Xiaoping Zhou, Honghao Wang, Hui Zhang, Wei |
author_facet | Guo, Zhen Wang, Youhong Zhao, Yu Jin, Yi An, Liang Wu, Bin Liu, Zhaoqian Chen, Xiaoping Zhou, Honghao Wang, Hui Zhang, Wei |
author_sort | Guo, Zhen |
collection | PubMed |
description | LncRNA GAS5 plays a tumor suppressive role in a variety of human cancers and promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. However, the role of GAS5 in nasopharyngeal carcinoma (NPC) remains elusive. The objective of the present study was to evaluate the effect of single nucleotide polymorphisms (SNPs) in GAS5 on treatment efficacy and toxicity in NPC patients receiving chemoradiotherapy. Three potentially functional SNPs of GAS5 were genotyped in 267 NPC patients and validated in another 238 NPC patients treated with chemoradiotherapy from southern China. Multivariate logistic regression analyses and stratification analyses were used to estimate the association of candidate SNPs and chemoradiotherapy efficacy and toxic reactions. Our results showed that rs2067079 kept a consistent association with severe myelosuppression and severe neutropenia in discovery set (OR=2.403, P=0.009; OR=2.454, P=0.015; respectively), validation set (OR=3.653, P=0.027; OR=4.767, P=0.016; respectively), and combined dataset (OR=1.880, P=0.007; OR=2.079, P=0.005; respectively). rs2067079 CT genotype carriers presented an even more remarkable increased risk of severe myelosuppression (OR=3.878, P=0.003) and severe neutropenia (OR=3.794, P=0.009) in subgroups taking paclitaxel+platinum as concurrent chemoradiotherapy regimen. Besides, we found a gene-does effect of rs6790, with the incidence rate of severe myelosuppression decreased from 23.56% to 17.21% to 10% and the incidence rate of severe neutropenia decreased from 30.4% to 20.9% to 17.1% for rs6790 GG vs GA vs AA genotype carriers. Our results indicate the potential role of lncRNA GAS5 polymorphisms rs2067079 and rs6790 as predictive biomarkers for chemoradiotherapy induced toxic reactions in NPC patients. |
format | Online Article Text |
id | pubmed-5617505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56175052017-10-03 Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients Guo, Zhen Wang, Youhong Zhao, Yu Jin, Yi An, Liang Wu, Bin Liu, Zhaoqian Chen, Xiaoping Zhou, Honghao Wang, Hui Zhang, Wei Oncotarget Research Paper LncRNA GAS5 plays a tumor suppressive role in a variety of human cancers and promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. However, the role of GAS5 in nasopharyngeal carcinoma (NPC) remains elusive. The objective of the present study was to evaluate the effect of single nucleotide polymorphisms (SNPs) in GAS5 on treatment efficacy and toxicity in NPC patients receiving chemoradiotherapy. Three potentially functional SNPs of GAS5 were genotyped in 267 NPC patients and validated in another 238 NPC patients treated with chemoradiotherapy from southern China. Multivariate logistic regression analyses and stratification analyses were used to estimate the association of candidate SNPs and chemoradiotherapy efficacy and toxic reactions. Our results showed that rs2067079 kept a consistent association with severe myelosuppression and severe neutropenia in discovery set (OR=2.403, P=0.009; OR=2.454, P=0.015; respectively), validation set (OR=3.653, P=0.027; OR=4.767, P=0.016; respectively), and combined dataset (OR=1.880, P=0.007; OR=2.079, P=0.005; respectively). rs2067079 CT genotype carriers presented an even more remarkable increased risk of severe myelosuppression (OR=3.878, P=0.003) and severe neutropenia (OR=3.794, P=0.009) in subgroups taking paclitaxel+platinum as concurrent chemoradiotherapy regimen. Besides, we found a gene-does effect of rs6790, with the incidence rate of severe myelosuppression decreased from 23.56% to 17.21% to 10% and the incidence rate of severe neutropenia decreased from 30.4% to 20.9% to 17.1% for rs6790 GG vs GA vs AA genotype carriers. Our results indicate the potential role of lncRNA GAS5 polymorphisms rs2067079 and rs6790 as predictive biomarkers for chemoradiotherapy induced toxic reactions in NPC patients. Impact Journals LLC 2017-07-31 /pmc/articles/PMC5617505/ /pubmed/28977945 http://dx.doi.org/10.18632/oncotarget.19725 Text en Copyright: © 2017 Guo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Guo, Zhen Wang, Youhong Zhao, Yu Jin, Yi An, Liang Wu, Bin Liu, Zhaoqian Chen, Xiaoping Zhou, Honghao Wang, Hui Zhang, Wei Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title | Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title_full | Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title_fullStr | Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title_full_unstemmed | Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title_short | Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
title_sort | genetic polymorphisms of long non-coding rna gas5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617505/ https://www.ncbi.nlm.nih.gov/pubmed/28977945 http://dx.doi.org/10.18632/oncotarget.19725 |
work_keys_str_mv | AT guozhen geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT wangyouhong geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT zhaoyu geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT jinyi geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT anliang geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT wubin geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT liuzhaoqian geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT chenxiaoping geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT zhouhonghao geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT wanghui geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients AT zhangwei geneticpolymorphismsoflongnoncodingrnagas5predictplatinumbasedconcurrentchemoradiotherapyresponseinnasopharyngealcarcinomapatients |