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A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk
OBJECTIVE: It remains inconclusive whether Hashimoto’s thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question. RESULTS: Twenty-seven eligible studies were selected, including 18 archiv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617515/ https://www.ncbi.nlm.nih.gov/pubmed/28977955 http://dx.doi.org/10.18632/oncotarget.18620 |
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author | Lai, Xingjian Xia, Yu Zhang, Bo Li, Jianchu Jiang, Yuxin |
author_facet | Lai, Xingjian Xia, Yu Zhang, Bo Li, Jianchu Jiang, Yuxin |
author_sort | Lai, Xingjian |
collection | PubMed |
description | OBJECTIVE: It remains inconclusive whether Hashimoto’s thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question. RESULTS: Twenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies. The mean rate of PTC among patients with HT ranged from 1.12% (selective FNA or thyroidectomy studies) to 40.11% (thyroidectomy studies). All three types of studies supported the correlation between HT and PTC. The overall pooled odds ratio (OR) of the PTC risk for HT (HT versus non-HT) was 2.12 (95% confidence interval [CI]: 1.78-2.52). METHODS: We searched all relevant published studies using the citation databases PubMed and Embase. The ORs and corresponding 95% CIs were calculated by the random-effects model for the association between HT and PTC. CONCLUSIONS: Our meta-analysis confirmed that HT predisposed patients to the development of PTC. |
format | Online Article Text |
id | pubmed-5617515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56175152017-10-03 A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk Lai, Xingjian Xia, Yu Zhang, Bo Li, Jianchu Jiang, Yuxin Oncotarget Meta-Analysis OBJECTIVE: It remains inconclusive whether Hashimoto’s thyroiditis (HT) predisposes patients to the development of papillary thyroid carcinoma (PTC). We conducted a meta-analysis of the available data to address this question. RESULTS: Twenty-seven eligible studies were selected, including 18 archival thyroidectomy studies, 6 fine-needle aspiration (FNA) studies, and 3 selective FNA or thyroidectomy studies. A total of 76,281 patients, including 12,476 cases of thyroid cancer, were included in these studies. The mean rate of PTC among patients with HT ranged from 1.12% (selective FNA or thyroidectomy studies) to 40.11% (thyroidectomy studies). All three types of studies supported the correlation between HT and PTC. The overall pooled odds ratio (OR) of the PTC risk for HT (HT versus non-HT) was 2.12 (95% confidence interval [CI]: 1.78-2.52). METHODS: We searched all relevant published studies using the citation databases PubMed and Embase. The ORs and corresponding 95% CIs were calculated by the random-effects model for the association between HT and PTC. CONCLUSIONS: Our meta-analysis confirmed that HT predisposed patients to the development of PTC. Impact Journals LLC 2017-06-27 /pmc/articles/PMC5617515/ /pubmed/28977955 http://dx.doi.org/10.18632/oncotarget.18620 Text en Copyright: © 2017 Lai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Meta-Analysis Lai, Xingjian Xia, Yu Zhang, Bo Li, Jianchu Jiang, Yuxin A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title | A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title_full | A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title_fullStr | A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title_full_unstemmed | A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title_short | A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
title_sort | meta-analysis of hashimoto’s thyroiditis and papillary thyroid carcinoma risk |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617515/ https://www.ncbi.nlm.nih.gov/pubmed/28977955 http://dx.doi.org/10.18632/oncotarget.18620 |
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