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Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy

BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment (18...

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Autores principales: Chan, Sheng-Chieh, Cheng, Nai-Ming, Hsieh, Chia-Hsun, Ng, Shu-Hang, Lin, Chien-Yu, Yen, Tzu-Chen, Hsu, Cheng-Lung, Wan, Hung-Ming, Liao, Chun-Ta, Chang, Kai-Ping, Wang, Jiun-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617533/
https://www.ncbi.nlm.nih.gov/pubmed/28977973
http://dx.doi.org/10.18632/oncotarget.15904
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author Chan, Sheng-Chieh
Cheng, Nai-Ming
Hsieh, Chia-Hsun
Ng, Shu-Hang
Lin, Chien-Yu
Yen, Tzu-Chen
Hsu, Cheng-Lung
Wan, Hung-Ming
Liao, Chun-Ta
Chang, Kai-Ping
Wang, Jiun-Jie
author_facet Chan, Sheng-Chieh
Cheng, Nai-Ming
Hsieh, Chia-Hsun
Ng, Shu-Hang
Lin, Chien-Yu
Yen, Tzu-Chen
Hsu, Cheng-Lung
Wan, Hung-Ming
Liao, Chun-Ta
Chang, Kai-Ping
Wang, Jiun-Jie
author_sort Chan, Sheng-Chieh
collection PubMed
description BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment (18)F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from (18)F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS). RESULTS: Multivariate analysis identified hypopharyngeal tumors (P = 0.038), alcohol drinking (P = 0.006), K(trans) ≤ 0.5512 (P = 0.017), and K(ep) ≤ 0.8872 (P = 0.005) as adverse prognostic factors for RFS. Smoking (p = 0.009), K(trans) ≤ 0.5512 (P = 0.0002), K(ep) ≤ 0.8872 (P = 0.004), and the PET heterogeneity parameter uniformity ≤ 0.00381 (P = 0.028) were independent predictors of poor OS. The combination of PET uniformity with DCE-MRI parameters and smoking allowed distinguishing four prognostic groups, with 3-year OS rates of 100%, 76.6%, 57.4%, and 7.1%, respectively (P < 0.0001). This prognostic system appeared superior to both the TNM staging system (P = 0.186) and the combination of conventional PET parameters with DCE-MRI (P = 0.004). CONCLUSIONS: Multiparametric imaging based on PET heterogeneity and DCE-MRI parameters combined with clinical risk factors is superior to the concomitant use of functional MRI coupled with conventional PET parameters. This approach may improve the prognostic stratification of OHSCC patients.
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spelling pubmed-56175332017-10-03 Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy Chan, Sheng-Chieh Cheng, Nai-Ming Hsieh, Chia-Hsun Ng, Shu-Hang Lin, Chien-Yu Yen, Tzu-Chen Hsu, Cheng-Lung Wan, Hung-Ming Liao, Chun-Ta Chang, Kai-Ping Wang, Jiun-Jie Oncotarget Clinical Research Paper BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment (18)F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from (18)F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS). RESULTS: Multivariate analysis identified hypopharyngeal tumors (P = 0.038), alcohol drinking (P = 0.006), K(trans) ≤ 0.5512 (P = 0.017), and K(ep) ≤ 0.8872 (P = 0.005) as adverse prognostic factors for RFS. Smoking (p = 0.009), K(trans) ≤ 0.5512 (P = 0.0002), K(ep) ≤ 0.8872 (P = 0.004), and the PET heterogeneity parameter uniformity ≤ 0.00381 (P = 0.028) were independent predictors of poor OS. The combination of PET uniformity with DCE-MRI parameters and smoking allowed distinguishing four prognostic groups, with 3-year OS rates of 100%, 76.6%, 57.4%, and 7.1%, respectively (P < 0.0001). This prognostic system appeared superior to both the TNM staging system (P = 0.186) and the combination of conventional PET parameters with DCE-MRI (P = 0.004). CONCLUSIONS: Multiparametric imaging based on PET heterogeneity and DCE-MRI parameters combined with clinical risk factors is superior to the concomitant use of functional MRI coupled with conventional PET parameters. This approach may improve the prognostic stratification of OHSCC patients. Impact Journals LLC 2017-03-04 /pmc/articles/PMC5617533/ /pubmed/28977973 http://dx.doi.org/10.18632/oncotarget.15904 Text en Copyright: © 2017 Chan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Chan, Sheng-Chieh
Cheng, Nai-Ming
Hsieh, Chia-Hsun
Ng, Shu-Hang
Lin, Chien-Yu
Yen, Tzu-Chen
Hsu, Cheng-Lung
Wan, Hung-Ming
Liao, Chun-Ta
Chang, Kai-Ping
Wang, Jiun-Jie
Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title_full Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title_fullStr Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title_full_unstemmed Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title_short Multiparametric imaging using (18)F-FDG PET/CT heterogeneity parameters and functional MRI techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
title_sort multiparametric imaging using (18)f-fdg pet/ct heterogeneity parameters and functional mri techniques: prognostic significance in patients with primary advanced oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiotherapy
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617533/
https://www.ncbi.nlm.nih.gov/pubmed/28977973
http://dx.doi.org/10.18632/oncotarget.15904
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