Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population

The aim of this study was to determine the association between nonalcoholic fatty liver disease (NAFLD) and asymptomatic gallstones in a Chinese population. The study had a cross-sectional design and enrolled 7583 subjects who visited the physical check-up center at Sir Run Run Shaw Hospital between...

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Autores principales: Qiao, Qiao-Hua, Zhu, Wen-Hua, Yu, Yun-Xian, Huang, Fei-Fei, Chen, Li-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617690/
https://www.ncbi.nlm.nih.gov/pubmed/28930823
http://dx.doi.org/10.1097/MD.0000000000007853
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author Qiao, Qiao-Hua
Zhu, Wen-Hua
Yu, Yun-Xian
Huang, Fei-Fei
Chen, Li-Ying
author_facet Qiao, Qiao-Hua
Zhu, Wen-Hua
Yu, Yun-Xian
Huang, Fei-Fei
Chen, Li-Ying
author_sort Qiao, Qiao-Hua
collection PubMed
description The aim of this study was to determine the association between nonalcoholic fatty liver disease (NAFLD) and asymptomatic gallstones in a Chinese population. The study had a cross-sectional design and enrolled 7583 subjects who visited the physical check-up center at Sir Run Run Shaw Hospital between 2009 and 2011. Colorimetric methods were used to measure the levels of cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), whereas fasting plasma glucose (FPG) level was measured using a dextrose-oxidizing enzyme method. Subjects who completed a questionnaire and underwent a medical and ultrasound examinations were included in the study. The prevalence of NAFLD was significantly higher in patients with asymptomatic gallstones than in those without asymptomatic gallstones (58.98% vs 46.58%, respectively; P < .0001). The age-adjusted odds ratio (OR) for NAFLD being accompanied by asymptomatic gallstones was 1.35 [95% confidence interval (CI), 1.13–1.61; P = .0009] in male and 1.92 (95% CI, 1.45–2.54; P < .0001) in female subjects. Asymptomatic gallstones were associated with NAFLD in subjects aged < 50 years (OR = 1.74, 95% CI, 1.44–2.12; P < .0001), but not in subjects aged > 50 years (OR = 1.17, 95% CI, 0.92–1.48; P = .2040). The OR of NAFLD for asymptomatic gallstones was 1.28 after multivariate logistic regression analysis (95% CI, 1.07–1.52; P = .006). Our results indicated that asymptomatic gallstones are strongly associated with NAFLD in the Chinese study population.
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spelling pubmed-56176902017-10-13 Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population Qiao, Qiao-Hua Zhu, Wen-Hua Yu, Yun-Xian Huang, Fei-Fei Chen, Li-Ying Medicine (Baltimore) 4500 The aim of this study was to determine the association between nonalcoholic fatty liver disease (NAFLD) and asymptomatic gallstones in a Chinese population. The study had a cross-sectional design and enrolled 7583 subjects who visited the physical check-up center at Sir Run Run Shaw Hospital between 2009 and 2011. Colorimetric methods were used to measure the levels of cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), whereas fasting plasma glucose (FPG) level was measured using a dextrose-oxidizing enzyme method. Subjects who completed a questionnaire and underwent a medical and ultrasound examinations were included in the study. The prevalence of NAFLD was significantly higher in patients with asymptomatic gallstones than in those without asymptomatic gallstones (58.98% vs 46.58%, respectively; P < .0001). The age-adjusted odds ratio (OR) for NAFLD being accompanied by asymptomatic gallstones was 1.35 [95% confidence interval (CI), 1.13–1.61; P = .0009] in male and 1.92 (95% CI, 1.45–2.54; P < .0001) in female subjects. Asymptomatic gallstones were associated with NAFLD in subjects aged < 50 years (OR = 1.74, 95% CI, 1.44–2.12; P < .0001), but not in subjects aged > 50 years (OR = 1.17, 95% CI, 0.92–1.48; P = .2040). The OR of NAFLD for asymptomatic gallstones was 1.28 after multivariate logistic regression analysis (95% CI, 1.07–1.52; P = .006). Our results indicated that asymptomatic gallstones are strongly associated with NAFLD in the Chinese study population. Wolters Kluwer Health 2017-09-22 /pmc/articles/PMC5617690/ /pubmed/28930823 http://dx.doi.org/10.1097/MD.0000000000007853 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4500
Qiao, Qiao-Hua
Zhu, Wen-Hua
Yu, Yun-Xian
Huang, Fei-Fei
Chen, Li-Ying
Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title_full Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title_fullStr Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title_full_unstemmed Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title_short Nonalcoholic fatty liver was associated with asymptomatic gallstones in a Chinese population
title_sort nonalcoholic fatty liver was associated with asymptomatic gallstones in a chinese population
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617690/
https://www.ncbi.nlm.nih.gov/pubmed/28930823
http://dx.doi.org/10.1097/MD.0000000000007853
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